Applications are invited for a Research Technical Assistant Position in
Structural Studies on Fcabs, Antibody Fragments with Antigen Binding
Properties.
Monoclonal antibodies (mAbs) are the most successful biologically
produced therapeutics today. They are applied for the treatment of many
different diseases, including cancer, autoimmune diseases, and
infectious diseases. Within the Christian Doppler Laboratory for
Antibody Engineeringcoordinated by Christian Obinger, new generations of
engineered mAbs with improved properties are being developed. Constant
domains (Fc) of human IgG1 are engineered by an integrated set of
approaches to (i) enhance their stability and folding, and (ii)
introduce _A_ntigen _B_inding sites by engineering the non-CDR loops.
Selected Fcabs will be characterized by various biophysical methods and
their structures alone and/or in complex with selected antigens
determined by X-ray crystallography.
As a Research Technician, you will be involved in protein production,
purification, and biophysical characterization, crystallization and
structure determination.
*Profile*
* Bachelor’s/Master’s degree in Biochemistry, Molecular Biology, or a
related field
* Excellent understanding of the theoretical and technical principles
of common techniques in protein biochemistry and molecular biology,
such as molecular cloning, protein expression and purification and
biophysical characterization
* Practical experience with molecular biology, protein purification,
protein biochemistry and insect and/or mammalian cell culture
* Experience with protein crystallization and structure determination
is a plus
Excellent command of English (spoken and written) is a must, German
skills are an asset.
Please send your application, including a letter of interest, a detailed
CV, and contact details for two references to *Kristina Djinovic Carugo
*(to e-mail: *[email protected]*) by *March 14th, 2014.*
Duration 2 years, salary 1400 Euro brutto, 25-30 hours/week. Starting
date: ASAP
**
*Kristina Djinovic Carugo*
/Department for Structural and Computational Biology/
Max F. Perutz Laboratories
University of Vienna
Campus Vienna Biocenter 5
A-1030 Vienna
Web Page: www.mfpl.ac.at/mfpl-group/group/djinovic.html#.UwznOF6jTfY
_E-mail: [email protected]_
*Christian Obinger*
/Department of Chemistry/
Vienna Institute of BioTechnology BOKU, Muthgasse 18
A-1190 Vienna
Web page:
forschung.boku.ac.at/fis/suchen.projekt_uebersicht?sprache_in=en&menue_id_in=300&id_in=7439
E-mail: [email protected] <mailto:[email protected]>
