Macromolecular Crystallography, Biophysics and Biochemistry
A post-doctoral fellowship position is available at the University of Texas
Medical Branch (UTMB) located in the greater Houston area in the research team
of Dr. Gabrielle Rudenko. We study molecules that mediate the formation,
maintenance and plasticity of synapses, the contact and communication point
between neurons. Our proteins of interest organize and regulate protein
interaction networks in the synaptic cleft and impact how neurons communicate
with each other at synapses. Many of the proteins we study are implicated in
neurological disease and serve as potential novel therapeutic targets.
We are looking for highly motivated, enthusiastic, hard working individuals who
are interested in combining the fields of structural biology and neuroscience.
Research projects involve protein over-expression and purification, x-ray
crystallography, biochemical and biophysical techniques, proteomics, chemical
biology and in collaboration electron microscopy and NMR.
Our laboratory is part of the endowed Sealy Center for Structural Biology and
Molecular Biophysics and the Department of Pharmacology/Toxicology at UTMB. The
Sealy Center provides access to exceptional facilities, training and
experimental assistance. X-ray facilities include a high-brilliance FR-E
Superbright x-ray generator, a Rigaku R-AXIS-IV dual 30cm Imaging Plate
detector, a Bruker SMART 2K CCD and a Rigaku BioSAXS-1000 2D-Kratky camera (for
solution scattering data). Biophysics facilities include equipment for
analytical ultracentrifugation, fluorescence, MALDI-TOF mass spectrometry,
dynamic light scattering, surface plasmon resonance, titration
micro-calorimetry, and high throughput screening with the ThermoFluor HTS
apparatus. In addition, the Electron Microscopy facilities house three modern
JEOL cryo-electron microscopes (a 200 keV JEOL 2200FS cryo-EM with in-column
electron energy filter and field emission gun, a 200 keV JEOL 2100 EM, and a
120 keV JEM1400 microscope) and the NMR facilities include three NMR
spectrometers (Bruker Avance III 800, 750 and 600 MHz with cryoprobes).
See http://www.scsb.utmb.edu/resources/
UTMB is part of the Texas Medical Center, the world’s largest medical center
located in greater Houston. UTMB has research facilities situated on Galveston
Island offering a pleasant subtropical climate and miles of relaxing beaches.
UTMB is located within commuting distance of Houston, the fourth largest city
in the United States and a leader in the arts, education, and health care.
Qualifications: Applicants should have received a Ph.D. degree in a field
relevant to structural biology within in the last three years and have a strong
publication record. Applicants with experience in cloning, bacterial/insect
cell culture, protein purification and crystallization, and macromolecular
structure determination are preferred. However, recent graduates with a strong
background in protein over-expression and purification, and an exceptional
interest in learning crystallography are also encouraged to apply. Good written
and oral communication skills in English are essential as well as the ability
and desire to work as part of a highly motivated, collaborative team.
To apply please e-mail the following to
[email protected]<mailto:[email protected]>: CV,
contact information for three references (address, phone and e-mail), a list of
your experimental expertise and skills relevant to this position and a research
statement describing your past research experience and future goals (1-2
pages). Visa sponsorship is available for non-US nationals. For questions,
please contact Dr. Gabrielle Rudenko at [email protected]
For more information please visit http://scsb.utmb.edu/labgroups/rudenko/
The University of Texas is a non-discriminatory, affirmative action employer.
Gabrielle Rudenko, PhD
Dept of Pharmacology and Toxicology
Sealy Center for Structural Biology & Biophysics
University of Texas Medical Branch
301 University Boulevard
Basic Sciences Building Rm. 5.114B
Galveston Texas 77555
