Post-doctoral fellowship (two years) on Structural Studies of DNA Polymerase Epsilon
We are looking for a highly motivated postdoctoral research fellow to join our laboratory at Umeå University, Sweden. We are interested in structure-function studies of yeast DNA polymerase epsilon (Pol ε) using a combination of x-ray crystallography, biochemistry and genetics. The candidate will participate in a project with the aim to mechanistically understand how Pol ε synthesizes DNA with high fidelity and high processivity. These studies expands to experiments addressing how Pol ε is directed to the leading strand in yeast. We recently published a high-resolution structure of the catalytic core of Pol ε (www.nature.com/nsmb/journal/v21/n1/full/nsmb.2712.html<http://www.nature.com/nsmb/journal/v21/n1/full/nsmb.2712.html> ). Our present aim is to obtain new high-resolution structures of Pol ε to learn more about the details in how Pol ε function. The work will include plasmid construction, over-expression and purification of proteins that will be studied. The structural work will be complemented with biochemical studies of Pol ε and other proteins which participate at the eukaryotic replication fork or in DNA repair. Qualifications: Successful candidates should have received a Ph.D. degree, preferably a background in structural biology. Good written and oral communication skills are essential. Preferred start is at the earliest possible date. Applicants should submit • a Curriculum Vitae • a statement of previous research achievements (max 1-2 pages) • a publication list • the names and contact information for three references Documents sent electronically should be in MS Word or PDF format. We are looking forward to receiving your application, preferably before May 29th. For more information, contact Erik Johansson at [email protected]<mailto:[email protected]>. Dept of Medical Biochemistry and Biophysics Web-page: www.medchem.umu.se/english/research/principal-investigators/johansson/<http://www.medchem.umu.se/english/research/principal-investigators/johansson/>
