Dear Colleagues,
The Protein Crystallography Station (PCS) is a high performance neutron beamline located at the spallation neutron source at the Los Alamos Neutron Science Center at Los Alamos National Laboratory. The PCS has a long-standing history of serving the neutron crystallographic community. The PCS is equipped with a 3He detector, offering high sensitivity and an adjustable 2-theta arm, allowing for collection of ultra-high resolution data (up to 1.1 Å data has been collected) using crystals as small as 0.3 mm 3. This is an excellent opportunity for traditional X-ray crystallographers interested in diverse aspects of structural biology such as enzyme mechanisms, protein dynamics, hydrogen bonding networks, and protonation states, to determine neutron derived structures of their target proteins. We also offer mail-in services for your protein crystals and routinely screen crystals using our in-house X-ray diffractometer. Full support for protein expression, purification, deuteration, and crystallization is also available, housed in a new laboratory space. *We are accepting proposals for our upcoming neutron beam run cycle starting 7 October 2014 and running until 26 February 2015. The deadline for receipt of proposals is 6 June 2014. * Proposals may be submitted by clicking on the “Apply for Beamtime” link in the left column of the Lujan home page: http://lansce.lanl.gov/lujan. Additional information about the PCS can be found at http://lansce.lanl.gov/lujan/instruments/PCS.shtml. We strongly encourage you to contact us for questions concerning sample preparation, instrument capabilities, sample environments, and/or proposal preparation. Julian Chen, [email protected] John Bacik, [email protected] Clifford Unkefer, [email protected]
