Hi, I have a protein that is prone to aggregation. I think the problem may be caused by a stretch of six-residues at the N-terminus that is predicted to form a beta-strand. I think this beta-strand is open ended and may form beta- sheets (similar to amyloid fibers) leading to the aggregation I observe. Are there any chemicals that would disrupt short beta-sheet formation? Thanks.
Best wishes, Reza Reza Khayat, PhD Assistant Professor The City College of New York Department of Chemistry, MR-1135 160 Convent Avenue New York, NY 10031 Tel. (212) 650-6070 www.khayatlab.org
