Hello everybody Why sometimes same enzyme of a homologous series from different organism show different affinity towards type of metal ion for its activity..Lets say threonine dehydratase from H pylori show maximum activity with Mg2+ as a cofactor while the same enzyme from Entamoeba histolytica showed maximum activity with Zn2+..while in others it is Mn2+..What could be the chemical or physical phenomenon for this difference ??..Can anybody suggest or name some good paper for this explanation..
-- Regards Faisal School of Life Sciences JNU
