Post-doctoral position “Structural studies of post-transcriptional / translational modification enzymes”.
Location: Palaiseau, Ecole Polytechnique, near Paris (30 minutes by regular trains), France A 2 years post-doctoral position, funded by the ANR (French National Research Agency), is available at Laboratory of Biochemistry, Ecole Polytechnique-CNRS (France). The successful candidate will work in a young and dynamic international team headed by Dr Marc Graille. He/She should have a PhD in protein biochemistry/structural biology. Expertises in cloning, protein purification and X-ray crystallography are required. Experience in RNA production and purification as well as in protein complexes reconstitution will be very much appreciated. The project aims at studying structural aspects of protein-protein and protein-RNA complexes involved in the post-transcriptional/translational modifications of eukaryotic factors involved in mRNA translation. It will be realized in collaboration with groups studying the role of these complexes in yeast or human cells. To address these questions, the successful candidate will use a large panel of biochemical (protein expression and purification, enzymology, pull-down, …) and biophysical methods (X-ray crystallography, ITC, MALLS, fluorescence, …), which are all implemented in the host laboratory (Laboratory of Biochemistry, Ecole Polytechnique-CNRS). The lab is also equipped with a state-of-the art crystallization platform (Tecan and Mosquito crystallization robots plus an automatic system for crystallization plates imaging) and is located 2 km away from the French synchrotron SOLEIL, which offers regular access to protein crystallography beam lines (Proxima-1 and 2). Recent publications from Dr Graille’s group related to the project: Létoquart et al, PNAS, in press. Figaro et al, Mol. Cell. Biol., 2012 Graille et al, Biochimie, 2012 (review) Liger et al, Nuc. Acids Res., 2011. van den Elzen et al; Nat. Struct. Mol. Biol, 2010 More information can be found on our website: http://bioc.polytechnique.fr/spip.php?rubrique117&lang=en . The Laboratory of Biochemistry has a long standing expertise in the study of translational apparatus and is located on the multidisciplinary “Ecole Polytechnique” campus, one of the most selective and prestigious French “Grande Ecole”, which attracts top undergraduate and graduate students worldwide. Ecole Polytechnique is located 25 km south from Paris and as regular train connections to Paris city centre (30 minutes). The campus offers all the equipments to perform various activities (music, theatre, …) or sports: swimming pools, 8 tennis courts, several football, volleyball and. basketball pitches, climbing walls, … More info on the campus can be found at : http://www.polytechnique.edu/en . Net annual salary: around 24,500€ minimum. Starting : 2015, depending on availability of selected candidate. Duration: 24 months. Applications (including CV, resume describing your relevant skills and a list of three references) or information requests should be sent to Marc Graille ([email protected]). Dr Marc GRAILLE Directeur de recherche CNRS Team: Translation and degradation of eukaryotic mRNAs Team supported by the ATIP-Avenir CNRS program Laboratoire de Biochimie ECOLE POLYTECHNIQUE - UMR7654 CNRS 91128 PALAISEAU CEDEX Phone : +33 (0)1 69 33 48 90 – Fax : +33 (0)1 69 33 49 09 Office 033012B Email: [email protected] http://bioc.polytechnique.fr/spip.php?rubrique117
