Dear all, We have positions open for a post-doc and a technician to study the structure and function of the zinc metalloprotease, ZMPSTE24.
Ø ZMPSTE24 is an integral membrane enzyme that is embedded in the inner membrane of the nucleus. Ø It is required for correct processing of nuclear lamins. Ø Failure of this process leads to premature ageing diseases such as Hutchinson Gilford Progeria syndrome. Ø We solved the structure of human ZMPSTE24 and found it has a unique fold, forming a huge cavity inside the nuclear membrane (Quigley et al., Science, 2013) Ø We plan to study how this enzyme cleaves lamins in two places and how errors in lamin or ZMPSTE24 lead to disease. Ø We will also study the structures of other enzymes involved in lamin processing and protein lipidation. We are seeking a post-doc and technician with a background in membrane protein structure and/or function to join our dynamic multidisciplinary team in Oxford. Informal enquiries can be addressed to [email protected]<mailto:[email protected]> To apply for these posts please follow this link: Post-doc: http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/116298-Postdoctoral-Scientist-Integral-Membrane-Protein Technician: http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/116393-Laboratory-Technician-Membrane-Protein-Production Applications before 12.00 noon on the 17th of December for the post-doc position and the 19 December 2014 for the Technician position please.
