Dear CCP4ers, Sorry for this non-structural biology related jobs announcements, but this will be very helpful if you could spread this message to who might be interested.
Two postdoctoral researcher positions are available in the Department of Medical Biochemistry and Biophysics at Karolinska Institutet (Stockholm, Sweden). The work will be done in Pär Nordlund's group who has developed a novel strategy for discovering clinical biochemical biomarkers that bear the potential to improve drug therapies for different cancers. The technology allows for the direct quantification of biochemical changes of activation states of proteins in patient samples using a biophysical principle - the Cellular Thermal Shift Assay (CETSA; Martinez Molina, Science 2013 41;84; Savitski, Science 2014 346:1255784). CETSA measurements of drug target engagement enables direct measurements of the extent to which a drug reaches and binds to its anticipated target in the cancer locus. Target engagement based CETSA biomarkers have the potential to optimize therapy in the individual patient, providing an entirely novel strategy within the emerging field of personalized medicine. The project aims to further develop and validate the CETSA technology in different cell and animal models and patient samples. The successful applicants will work in a dynamic team, developing new implementations of CETSA for application in studies of mechanisms of drug action and resistance development and for discovery of diagnostic markers of therapeutic effect. External collaboration with pharmaceutical companies, research groups, clinicians, biobanks etc will be important in the project. Here are the links to get more details and to apply for the two positions: https://ki.mynetworkglobal.com/en/what:job/jobID:61201/where:4/ https://ki.mynetworkglobal.com/en/what:job/jobID:61205/where:4/ Thank you for your help ! Regards /lionel Lionel Trésaugues | PhD Department of Medical Biochemistry and Biophysics | Karolinska Institutet SE-171 77 Stockholm | Scheeles väg 2 +46 8 524 868 73 | +46 7 042 171 87 [email protected]<mailto:[email protected]> | ki.se<http://ki.se/ki/jsp/polopoly.jsp;jsessionid=aMdk8ad4iRL6OYOdFn?l=en&d=130> ______________________________________ Karolinska Institutet - a medical university
