Hi All,

perhaps rank scaling of maps as described here

Acta Cryst. (2014). D70, 2593-2606

instead of "sigma" scaling is a way to eliminate the ambiguity inherent to
"sigma" scaling.

Pavel

On Wed, May 27, 2015 at 1:31 PM, Gerard Bricogne <[email protected]>
wrote:

> Dear Sagar and Pavel,
>
>      Yes, it may be model bias, but you also have to bear in mind that
> the rmsd that is used as a unit in the choice of contouring level
> should not be thought of as the standard deviation of a Gaussian
> random variable and therefore implicitly associated to a "significance
> level" relative to a noise level. This is unfortunately a widespread
> misconception.
>
>      We have seen a case where an entire copy of a molecule had been
> missed at first because its density was visible only at a contour
> level of 0.35 "sigma", which at first sight would make anybody shrink
> back in horror. When it was nevertheless modelled and refined, there
> was no doubt whatsoever that it was there, making perfectly sensible
> contacts with its nearest neighbour molecules, obeying good NCS with
> the already placed copies and markedly improving the fit to the data.
> The peculiarity of that extra copy was that a clash around a symmetry
> element with its symmetry mate caused it to have a mean B-factor that
> was twice that of the other, well-ordered, copies of the molecule.
>
>      Now, if you look at the expression for the Debye-Waller factor in
> real space, you will find the B-factor raised to the power 3/2 in the
> denominator. That means that the blurring effect of that D-W factor in
> real space results in a lowering of the maximum value of an atomic
> electron density to which it is applied by B^(3/2).
>
>      The consequence is that electron density for a molecule whose
> mean B-factor is double that of another molecule will look similar at
> a contour level of 1.0/(2^(3/2)) = 0.35 to what the other molecule
> looks like when examined at a contour level of 1.0.
>
>      It is therefore a good idea to remember that the "sigma" level is
> mainly determined by the better-ordered region(s) of the molecule(s)
> present in the asymmetric units, and that less-well ordered regions
> will automatically have a contouring level handicap that is not to be
> automatically interpreted as a lower level of significance. Omit maps
> are a good idea of course, but do bear in mind the (B/B0)^(-3/2)
> effect, where B0 is the mean B in the well-ordered region, and B is
> the same quantity in a less well ordered one. Above all, don't confuse
> "sigma" with a noise level!
>
>
>      With best wishes,
>
>           Gerard.
>
> --
> On Wed, May 27, 2015 at 12:18:25PM +0100, Pavel Afonine wrote:
> > Sagar,
> >
> > what you see may be model bias unless you calculated these maps without
> > that region of molecule.
> >
> > Pavel
> >
> > On Wed, May 27, 2015 at 12:03 PM, Sagar De'Biomimic <
> > [email protected]> wrote:
> >
> > > Dear all,
> > >
> > > We have solved a structure of Protein-DNA complex. In an ASU we have
> two
> > > protein homodimers and two DNA duplexes. Additionally we were able to
> model
> > > N-terminal region (NTR) missing in the previously reported structure.
> > >
> > > I had modelled poly-alanine chains in the positive density and refined.
> > > These chains were then joined to form NTR. Finally the entire NTR was
> > > refined for occupancies.
> > >
> > > I am doubtful about the validity of modelling of NTR as i had dropped
> down
> > > sigma levels to as low as 0.8 (as i could not see much of the noise) of
> > > FO-FC and modelled in positive density. After refinment the region
> shows
> > > the density at 0.5 sigma level of 2FO-FC. I have attached a pdf file
> > > showing snapshots of NTR at 0.4, 0.5, 0.6, 0.7 sigma level of 2FO-FC
> map.
> > >
> > > I would like to know crystallography community's opinion on validity of
> > > such modelling.
> > >
> > > This NTR region is highly flexible. Main intention of modelling it in
> such
> > > a weak signal was to complete the model for our Molecular dynamics
> > > studies.
> > >
> > > Additionally we have confirmed with SAXS DATA using Ensemble optimised
> > > modelling (EOM 2.0), the high flexibility and multiple conformations of
> > > this NTR region.
> > >
> > > I would like to know if there is a possibility of having a tool
> similar to
> > > EOM to model highly flexible regions of a protein in electron Density.
> As
> > > far as I know xMDFF does better at lower resolutions but fails to model
> > > highly flexible regions such as ours.
> > >
> > > Thank you.
> > >
> > > Regards
> > >
> > > Sagar
> > >
> > >
> > >
> > > --
> > > Sagar Khavnekar
> > > Project student,
> > > Structural Biology and Molecular Biophysics lab,
> > > UM-DAE Centre for Excellence in Basic Sciences
> > > University of Mumbai, Vidyanagari Campus, Kalina, Santacruz (East)
> > > Mumbai 400098, India.
> > >
>
> --
>
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>      * Gerard Bricogne                     [email protected]  *
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