Postdoctoral Position in Membrane Structural and Functional Biology A BBSRC-funded position is available immediately in Professor Adrian Goldman’s laboratory at the University of Leeds
School/Institute: School of Biomedical Sciences Salary: £31,342 to £37,394 per annum Contract Type: Fixed Term (36 months) Closing Date: Tuesday 07 July 2015 Fixed Term for 36 months to start by 1 September 2015 Project Title: The integral membrane H+-pumping pyrophosphatase from the malaria parasite: a new drug target This position is to study the structure and function of integral membrane H+-pumping pyrophosphatase, aiming to determine the full pumping mechanism and to use the structure for drug design, aiming to find molecules that specifically inhibit this novel pump and so affect malarial and other protozoan parasites’ infectivity. The project combines production purification with crystallisation, crystallography and electrophysiological measurements to determine the structure and mechanism. You will work in the multidisciplinary School of Biomedical Sciences, which includes biochemists and physicists, and as part of the Astbury Centre for Structural Molecular Biology. You will be supervised by Professor Adrian Goldman (SBMS), and the work will involve close collaboration with the University of Helsinki (Dr Henri Xhaard and Professor Seppo Meri) and with Drs. Roman Tuma and Sarah Harris at the University of Leeds. You will be a highly motivated individual with a strong basis in microbiology/pathology/structura biology, and experience in working with membrane proteins. You will have a PhD (or be close to completion) and have previous experience of protein expression and purification, tissue culture and ideally experience of working with biosafety level 2 pathogens. Informal enquiries may be made to Professor Adrian Goldman, tel +44 (0)113 343 8537, email [email protected] The full application form and information can be found at: https://jobs.leeds.ac.uk/vacancy.aspx?ref=FBSBM1018
