Protein Crystallographer
Heptares is a Drug Discovery Company located in Hertfordshire UK, working on G protein-coupled receptors (GPCRs) involved in CNS and metabolic diseases. Our unique structure-based approach to discovering therapeutic agents for these diseases relies on a proprietary approach to stabilise GPCRs, enabling their purification for structural and biophysical studies. We are currently seeking an experienced protein crystallographer to join the crystallography group working on GPCR structure determination to enable drug discovery efforts. Applicants should have a PhD in protein crystallography or related discipline and be familiar with purification of proteins from recombinant expression systems such as E. coli or baculovirus/insect cells, setting up crystallisation experiments including Lipidic Cubic Phase crystallisation, X-ray data collection, data processing, structure solution and refinement of novel structures and follow on complexes. Experience working with GPCRs or other membrane proteins would be an advantage. Experience of working in a drug discovery environment where structural studies are used to drive compound design and medicinal chemistry would also be of benefit. The successful candidate will be expected to work independently and within a highly successful group to: Express and purify GPCRs for structural and biophysical methods; Set up and optimise vapour diffusion and LCP crystallisation experiments; Collect X-ray diffraction data at synchrotron sources; Solve and refine structures; Assist with interpretation of structural results for the design of new compounds; Present results (written and oral) to internal and external audiences. This is an exceptional opportunity to participate in pioneering science with an Industry-leading Drug Discovery company. Applicants must be able to demonstrate proof of the right to work in the United Kingdom. Further information can be found on our website (www.heptares.com<http://www.heptares.com>). Applications should include a covering letter with curriculum vitae including the names and contact details for two referees. Please send your application in pdf format, to [email protected]<mailto:[email protected]> quoting reference number 2015/1B. The closing date for applications is 31st July 2015. No agencies, please. ----- Dr. Andrew S. Doré DPhil Associate Director Biomolecular Structure Heptares Therapeutics Ltd BioPark, Broadwater Road, Welwyn Garden City, Herts, AL7 3AX UK [www.heptares.com]<www.heptares.com><http://www.heptares.com> The information in this e-mail is confidential and may be legally privileged. It is intended for the exclusive attention of the addressee stated above and should not be copied or disclosed to any other. If you have received this transmission in error, please make no use of its contents and contact the sender. Contact and registered office address: Heptares Therapeutics Limited, BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire, AL7 3AX. Company No: 06267989
