Dear all, We are seeking a highly motivated and determined membrane protein structural biologist for a UK research council funded position in Liz Carpenter's group at the Structural Genomics Consortium in Oxford, to start asap.
1. Structural studies of human K2P potassium channels * We will build on our successful program of solving K2P ion channel structures (Dong et al., Science, 2015) * The K2P channels are responsible for excitability of nerve cells and are potential targets for migraine, pain and depression. * We aim to understand regulation of these channels by physiological and pharmacological stimuli * You will be using synchrotron and xFEL crystallography techniques to study the structures of a range of K2P channels * You will use biophysical methods to understand function and identify novel binders * You would also have the opportunity to be involved in structural studies of other potassium channels, using crystallography and electron microscopy * This work is a collaboration with Stephen Tucker (Physics, Oxford) and Mark Sansom (Biochemistry, Oxford), for electrophysiology and MD simulations studies. * Informal enquires to [email protected]<mailto:[email protected]> * Closing date for applications: Monday, 7th of November, 2016 * Please follow this link to apply for this post: http://www.ndm.ox.ac.uk/current-job-vacancies/vacancy/125728-Postdoctoral-Research-Scientist---Integral-Membrane-Protein-Group With best wishes, Liz Carpenter Professor of Membrane Protein Structural Biology, Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford.
