Dear all, I’m looking foran enthusiastic and highly motivated PhD student to join my newly establishedgroup at IGBMC, Strasbourg, France. We are studying the structure and functionof the dynein motor protein through an integrated structural biology approachcombining x-ray crystallography and high-resolution cryoEM. The dynein motor isa complex and fascinating molecular machine involved in essential cellular processeslike mitosis, organelle positioning and the beating of cilia (https://www.ncbi.nlm.nih.gov/pubmed/24064538). Applicantsshould possess a Master’s or Bachelor’s degree in the life sciences, or arelated discipline. The applicant should have experience in molecular biologyas well as protein expression and purification. Experience in proteinexpression in yeast and/or insect cells would be considered an advantage.Training in x-ray crystallography and cryoEM will be provided. English languageskills, the ability to work in a team, initiative, flexibility as well as goodorganizational and learning skills are required. The IGBMC (http://www.igbmc.fr/) is one of the leading biomedicalresearch institutions in Europe and provides regular synchrotron access as wellas cutting-edge cryo-EM facilities like a Titan Krios electron microscopeequipped with a Cs corrector, a GIF energy filter, a phase plate and a Gatansummit K2 direct electron detector. An ion beam scanning electron microscope(cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellulartomography studies are also available. Applicantsshould send a CV, a one-page summary of their research experience and contactdetails for two referees till 31st of March to [email protected] starting date is flexible. Selectedpublications: Schmidt H(2015) “Dynein motors: How AAA+ ring opening and closing coordinatesmicrotubule binding and linker movement.” Bioessays:37: 532-543. Schmidt H, Zalyte R, Urnavicius L, Carter AP(2015) “Structure of human cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438. Schmidt H,Gleave ES, Carter AP (2012) “Insights into dynein motor domain function from a3.3-Å crystal structure” Nat Struct MolBiol. 19:492-7.
