A three-year postdoctoral position for a biochemist/structural biologist is available in the Department of Biochemistry, University of Cambridge, England. The Department has state-of-the-art equipment and facilities, including crystallization robots, NMR, cryo-EM, biophysics, metabolomics, and easy access to synchrotron beamlines and confocal microscopy. The postdoctoral position is available immediately with Dr Monique Gangloff following a New Investigator Research Grant award to study mosquito vector innate immunity.
We are looking for a highly motivated postdoctoral Fellow with a strong interest in Structural Biology, Signalling and Vector Biology. The project investigates the structure and function of mosquito immune receptors that have diverged and undergone gene duplication under the influence of selective pressure by pathogenic parasites and viruses, potentially acquiring new functions relating to host-pathogen homeostasis. You will gain in-depth experience in Structural Biology by determining receptor-ligand complex structures using either X-ray crystallography or complementary techniques such as Small Angle X-ray Scattering (SAXS) and high-resolution cryo-EM. You will establish cell-based assays to verify predicted structure-function relationships. It is expected that you present your results at scientific conferences and write/publish scientific papers in high-quality, peer-reviewed journals. Essential requirements: PhD in biochemistry, molecular and cellular biology, or related disciplines Strong background in construct design, molecular biology and protein purification Significant experience with biophysical and structural techniques Strong organizational and interpersonal skills A proven record of work published in reputable scientific journals. Desirable requirements: Experience of protein expression methods using prokaryotic and eukaryotic in particular insect cell expression systems Proficiency in cell-based signaling assays to establish novel luciferase reporter assays in mosquito cell lines Knowledge in ligand fishing experiments using Mass Spectrometry Experience of working with Protein Crystallization, X-ray crystallography, SAXS, cryo-EM, Isothermal Titration Calorimetry and Surface Plasmon Resonance. To apply online for this vacancy, please visit http://www.jobs.cam.ac.uk/job/13256/ <http://www.jobs.cam.ac.uk/job/13256/> then click on the 'Apply' button. This will route you to the University's Web Recruitment System, where you will need to register an account (if you have not already) and log in before completing the online application form. The application should include a cover letter describing the candidate's research interests and motivation to apply, the CV and list of publications, and contact details of three referees. Any enquires regarding the application process can be directed to Adriana Dote ([email protected] <mailto:[email protected]>). Informal enquiries are welcome and can be made to Dr. Monique Gangloff ([email protected] <mailto:[email protected]>). Please quote reference PH11763 on your application and in any correspondence about this vacancy. The University values diversity and is committed to equality of opportunity. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
