Postdoctoral Research Position in Structural Biology of Phosphoinositide Signaling
The mechanistic Target of Rapamycin (mTOR) is involved in sensing amino-acid availability, oxygen, ATP levels and growth-factor signalling. Its activity coordinates mRNA translation, lipid metabolism, mitochondrial functions, ribosome biogenesis and autophagy. The Ragulator and Rhebulator complexes control mTORC1 through two types of small GTPases, the Rags and Rheb. The three-year Cancer Research UK funded position focuses on the structural biology of mTORC1 assembled with its regulators on lysosomal membranes. The research group of Roger Williams in the MRC Laboratory of Molecular Biology has an opening for a Postdoctoral Scientist to carry out structural and functional studies of mTOR-containing complexes. The programme involves cryo-electron microscopy, X-ray crystallography, H/D exchange mass spectrometry, as well as other biophysical and biochemical approaches. Applicants should have a PhD in a relevant subject (e.g., biology, chemistry, biochemistry, or physics) or, exceptionally, equivalent experience. Applicants should also have a strong interest in structure-function studies of protein complexes. Experience in electron microscopy, crystallography or mass spectrometry is desirable. The successful applicant will be awarded a 3 year Career Development Fellowship/MRC Postdoctoral Training Scheme. The fellowship is a training and development position for a Postdoctoral Scientist who has recently completed their doctoral studies, or is moving into a new research discipline. Working for the MRC provides a whole host of benefits including a final salary pension scheme, Benenden Healthcare membership and excellent holiday entitlement. You will also have access to employee shopping/travel discounts, on site sport and social facilities, as well as salary sacrifice cycle to work schemes and childcare vouchers. The MRC Laboratory of Molecular Biology is one of the birthplaces of molecular biology and is an internationally renowned centre for fundamental biomedical research. The LMB has an excellent record of innovative basic research leading to applications in medicine. Scientists are drawn to the LMB from all over the world, thus creating a lively and international community for the exchange of ideas and technical innovation. For further information of the research undertaken at the LMB, please visit: http://www2.mrc-lmb.cam.ac.uk <http://www2.mrc-lmb.cam.ac.uk/> or write to Roger Williams ([email protected] <mailto:[email protected]>) To apply and access full details of the vacancy please visit our job board at https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/573 <https://mrc.tal.net/vx/lang-en-GB/appcentre-1/candidate/postings/573>. If you are unable to apply online please contact us at [email protected] <mailto:[email protected]> . Closing date: 7th May 2017 Final appointments will be subject to a pre-employment screening. The Medical Research Council is an Equal Opportunities Employer who participates in the Disability Confident scheme Roger Williams [email protected] MRC Laboratory of Molecular Biology Francis Crick Avenue Cambridge Biomedical Campus Cambridge CB2 0QH, UK Phone lab: +44 1223 267094
