A PhD position in structural biology is available at the department of
biochemistry of the Biocenter of the Julius Maximilians University,
Wuerzburg/Germany.
The topic of the work will be the structural organization of the SMN
complex. This megadalton-sized molecular machine assembles U snRNP
particles, the basic building blocks of the spliceosome. Genetic
defects of its name-giving core component, the SMN protein, are the
cause of the devastating neuromuscular disease spinal muscular atrophy
(SMA). Our group has recently solved the structure of key components
of the SMN complex bound to substrate Sm proteins (Grimm et al., Mol
Cell. 2013 49(4):692-703). The planned work will continue these
efforts and characterize large entities of the SMN complex.
The successful candidate will work mainly in the field of
crystallography and optimize, express and purify protein constructs
and complexes for structural studies.
Please send your application including a letter of interest,
curriculum vitae and academic certificates to:
Dr. Clemens Grimm
e-mail: clemens.gr...@biozentrum.uni-wuerzburg.de
Lehrstuhl für Biochemie
Biozentrum der Universitaet Wuerzburg
Am Hubland
D-97074 Wuerzburg
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Dr. Clemens Grimm
Institut für Biochemie
Biozentrum der Universität Würzburg
Am Hubland
D-97074 Würzburg
Germany
e-mail: clemens.gr...@biozentrum.uni-wuerzburg.de
phone : +49 0931 31 84031
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