Dear ccp4 enthusiasts,
There are two positions available in my lab at Brown University. More
information below, and feel free to email me.
Thanks,
Alexandra
*POSTDOCTORAL POSITION*
*at Brown University (Structural Biology)*
The Deaconescu Lab at Brown University is seeking a postdoctoral
researcher. The laboratory's interest is the stress response and the
interplay between DNA repair and other cellular processes including
transcription and chromatin remodeling, and is focused on elucidating
the function and mechanochemistry of DNA-based motors using a
combination of biochemical, biophysical and structural techniques. (e.g.
X-ray crystallography, small-angle X-ray scattering, transmission
electron microscopy). For examples of work, please see*Deaconescu et
al., PNAS (2012), Szyk et al, Cell (2014), Szyk et al., NSMB (2012) and
Deaconescu et al., TIBS (2013)*. A successful candidate should have the
following qualifications: a Ph.D. in the field of Molecular Biology,
Cell Biology, Biochemistry or related field; an established track-record
of publications in peer-reviewed journals; solid experience in the
biochemistry of complex DNA-binding proteins (such as chromatin
remodeling factors or DNA repair proteins), their purification from
heterologous expression systems as well as their characterization using
functional studies such as by isothermal titration calorimetry
fluorescence, transcription assays.Prior knowledge of crystallography is
highly desirable. Must be highly motivated and work independently as
well as in a team. Excellent spoken and written English are required.
New Ph.D. graduates are encouraged to apply. More information at
http://www.deaconesculab.com
*Interested candidates should send a CV, one page research experience
summary and contact information for three references to
**[email protected]*
<mailto:[email protected]>*.*Salary and starting date are
negotiable.Please write Postdoctoral Candidate in the e-mail subject
header.Brown University, an Ivy League school, is located less than one
hour away by train from Boston.
*RESEARCH TECHNICIAN POSITION*
*At Brown University (Structural Biology)*
**
The Deaconescu Lab at Brown University (Providence, RI) is seeking a
highly motivated individual to work as a Research Assistant. The
Deaconescu Laboratory focuses on structural studies by X-ray
crystallography, small-angle X-ray scattering and electron microscopy of
protein-protein and protein-nucleic acid complexes, particularly those
involved in DNA repair and transcriptional regulation. The desired
candidate will be responsible for performing routine lab work including
media preparation, the preparation of solutions and stocks, cloning,
large-scale protein expression, protein purification using an Akta
chromatographic system, protein characterization using functional and
biophysical methods (fluorescence, activity assays, circular dichroism,
ITC), and protein crystallization. Additional responsibilities include
performing general lab administration, which includes the organization
and maintenance of lab databases and stocks, ordering, data entry and
other duties as assigned. Applicant should be highly motivated with
thorough, methodological and accurate work habits. The ideal candidate
has a strong ability to multi-task and good communication skills.More
information at http://www.deaconesculab.com
_Qualifications:_Bachelor's or Master’s degree in a biological science
or chemistry is required. Biological laboratory experience is required.
Previous experience with molecular biology techniques (PCR, vector
construction, nucleic acid extraction), protein expression, biochemistry
(protein purification, enzyme assays, immunoblotting), protein
crystallization are *_highly desirable_*. *To apply, please send a CV,
undergraduate transcript and contact information for three references to
**[email protected]*
<mailto:[email protected]>*. *Write “technician candidate”
in the subject line. Position is available immediately, but start date
is flexible.
--
Alexandra Deaconescu, B.E., Ph.D.
Assistant Professor
Brown University
Office: (401) 863-3215
Wet Lab: (401) 863-6729
Computational Lab: (401) 863-7031
For Mail:
Laboratories of Molecular Medicine
70 Ship St. GE-4
Providence, RI 02903
For Courier:
Laboratories of Molecular Medicine
Brown University
70 Ship St., Chestnut St. Loading Dock
Providence, RI 02903
Website: www.deaconesculab.com
Admin
Mr. Ray Windsor
Email: Raymond_Windsor[at]brown.edu
Mailing Address:
Box G-E, Brown University,
Providence, RI 02912-G
Telephone: (401) 863-7446
