Dear all,

*A two-year postdoctoral fellowship, funded by the Carl Tryggers Foundation, is available in the group of Julia Griese in the Department of Cell and Molecular Biology at Uppsala University, Sweden. *

Research in the Griese lab is at the intersection of structural biology, molecular biology and microbiology. We use X-ray crystallography in combination with a broad range of biochemical, biophysical and molecular biology techniques to understand the regulatory mechanisms governing prokaryotic metal homeostasis on a molecular and systemic level. The successful candidate will work within the project “Structural and functional characterization of metalloregulators in an actinomycete model organism”, with the aim to study the links between manganese and iron homeostasis and the oxidative stress response in this model organism. Please see ** <>for more information about our research.

We are looking for a person with excellent track record and motivation to identify and solve scientific problems. The postdoctoral fellow will work on a project investigating the metalloregulatory network of the model organism /Saccharopolyspora erythraea, /with a focus on manganese and iron homeostasis and links to the oxidative stress response. This will involve genetic manipulation of the host organism to introduce reporter genes and create knock-outs, and physiological studies of the resulting strains, as well as functional characterization of the metal-sensing transcription factors /in vitro/ by different biochemical and/or biophysical techniques, depending on the successful candidate’s expertise and interests. The successful candidate will work in close collaboration with another postdoctoral researcher focusing on the structural characterization of the metal sensors. The group is hosted in an international, multidisciplinary and dynamic environment with extensive opportunities to learn new techniques.

   Required qualifications

 * A PhD in molecular biology, microbiology, biochemistry or a related
 * Documented experience of molecular biology.
 * Demonstrated scientific excellence; evidenced by publication track
   record as well as track record of presenting at national and
   international meetings.
 * Excellent oral and written communication skills in English.
 * Good interpersonal skills.

   Desired additional qualifications

 * Experience of biochemical or biophysical techniques such as
   DNA-binding assays, isothermal titration calorimetry or fluorescence
 * Experience of promoter assays.
 * Experience of cultivation and genetic manipulation of actinomycetes.
 * Experience with metal- and/or DNA-binding proteins.

   The application should be written in English and include:

1. Letter of motivation with a short description of your research
   interests, and why you feel you are a good match for the project
   (one page).
2. CV, including a description of relevant skills and experiences, as
   well as a full publication list.
3. Copy of degree diploma and other official transcripts.
4. Names, e-mail addresses and telephone numbers to 2-3 reference
   persons. State their professional relation to you (e.g. PhD supervisor).

In the event of special circumstances leading to a career break, these should be mentioned in the CV (with dates) so that the assessment of scientific output can take these factors into account. Examples of such special circumstances include a leave of absence due to sickness, parental leave, serving on commissions of trust, military service etc.


*Starting date:*As soon as possible. Please indicate approximate starting date.


*Informal inquiries and applications should be sent to Julia Griese, *** <>*, with subject header “Postdoc in Molecular Biology”, no later than March 31, 2018. *

Are you considering moving to Sweden to work at Uppsala University? If so, you will find a lot of information about working and living in Sweden at ** <>.

Best regards,


-- Dr. Julia Griese Assistant Professor Department of Cell and Molecular Biology Uppsala University BMC, Box 596 SE-75124 Uppsala Sweden email:

Reply via email to