*A two-year postdoctoral fellowship, funded by the Carl Tryggers
Foundation, is available in the group of Julia Griese in the Department
of Cell and Molecular Biology at Uppsala University, Sweden. *
Research in the Griese lab is at the intersection of structural biology,
molecular biology and microbiology. We use X-ray crystallography in
combination with a broad range of biochemical, biophysical and molecular
biology techniques to understand the regulatory mechanisms governing
prokaryotic metal homeostasis on a molecular and systemic level. The
successful candidate will work within the project “Structural and
functional characterization of metalloregulators in an actinomycete
model organism”, with the aim to study the links between manganese and
iron homeostasis and the oxidative stress response in this model
organism. Please see *www.icm.uu.se/structural-biology/griese-lab/*
information about our research.
We are looking for a person with excellent track record and motivation
to identify and solve scientific problems. The postdoctoral fellow will
work on a project investigating the metalloregulatory network of the
model organism /Saccharopolyspora erythraea, /with a focus on manganese
and iron homeostasis and links to the oxidative stress response. This
will involve genetic manipulation of the host organism to introduce
reporter genes and create knock-outs, and physiological studies of the
resulting strains, as well as functional characterization of the
metal-sensing transcription factors /in vitro/ by different biochemical
and/or biophysical techniques, depending on the successful candidate’s
expertise and interests. The successful candidate will work in close
collaboration with another postdoctoral researcher focusing on the
structural characterization of the metal sensors. The group is hosted in
an international, multidisciplinary and dynamic environment with
extensive opportunities to learn new techniques.
* A PhD in molecular biology, microbiology, biochemistry or a related
* Documented experience of molecular biology.
* Demonstrated scientific excellence; evidenced by publication track
record as well as track record of presenting at national and
* Excellent oral and written communication skills in English.
* Good interpersonal skills.
Desired additional qualifications
* Experience of biochemical or biophysical techniques such as
DNA-binding assays, isothermal titration calorimetry or fluorescence
* Experience of promoter assays.
* Experience of cultivation and genetic manipulation of actinomycetes.
* Experience with metal- and/or DNA-binding proteins.
The application should be written in English and include:
1. Letter of motivation with a short description of your research
interests, and why you feel you are a good match for the project
2. CV, including a description of relevant skills and experiences, as
well as a full publication list.
3. Copy of degree diploma and other official transcripts.
4. Names, e-mail addresses and telephone numbers to 2-3 reference
persons. State their professional relation to you (e.g. PhD supervisor).
In the event of special circumstances leading to a career break, these
should be mentioned in the CV (with dates) so that the assessment of
scientific output can take these factors into account. Examples of such
special circumstances include a leave of absence due to sickness,
parental leave, serving on commissions of trust, military service etc.
*Starting date:*As soon as possible. Please indicate approximate
*Informal inquiries and applications should be sent to Julia Griese,
**julia.gri...@icm.uu.se* <mailto:julia.gri...@icm.uu.se>*, with subject
header “Postdoc in Molecular Biology”, no later than March 31, 2018. *
Are you considering moving to Sweden to work at Uppsala University? If
so, you will find a lot of information about working and living
in Sweden at *www.uu.se/joinus* <http://www.uu.se/joinus>.
-- Dr. Julia Griese Assistant Professor Department of Cell and Molecular
Biology Uppsala University BMC, Box 596 SE-75124 Uppsala Sweden email: