I am recruiting for a 5 year Wellcome Trust funded postdoc position in my lab 
at the University of St Andrews. The postdoc will work on a very 
multidisciplinary project using enzymology, chemical biology, x-ray 
crystallography and microbiology to study antimicrobial peptides.  

The add can be found in this link 
(http://www.jobs.ac.uk/job/BIO625/research-fellow-in-enzymology-ar2058sb/), and 
the position description and further particulars are below. 
Research Fellow in Enzymology - AR2058SB
University of St Andrews - School of Biology
Location:       St Andrews
Salary: £32,548 to £38,833 per annum
Hours:  Full Time
Contract Type:  Fixed-Term/Contract
Placed on:      20th March 2018
Closes: 20th April 2018
Job Ref:        179139
Start: 1 July 2018 or as soon as possible thereafter

Fixed term for 59 months

We are seeking to appoint a post-doctoral research assistant in enzymology to 
work on the characterisation and engineering of enzymes involved in the 
biosynthesis and modification of peptide antimicrobials. The position is 
available in Dr Clarissa Czekster’s lab at the School of Biology/Biomedical 
Sciences Research Complex (BSRC) at the University of St Andrews. The post is 
for 59 months, funded by the Wellcome Trust.

The successful candidate will be a creative, well-motivated and ambitious 
scientist who has completed (or is about to complete) his/her PhD in 
Biochemistry or related fields, and will have a track record in cloning, 
expression and purification of recombinant proteins, enzyme kinetics, and tRNA 
biochemistry. Experience in x-ray crystallography, tRNA production, mass 
spectrometry and chemical biology techniques are desirable. She/he will have 
all the essential skills and several of the desirable skills, evidenced by a 
strong publication record, recommendation letters and interview. The successful 
candidate will have strong motivation, initiative, and aspiration to set up new 
techniques, interact with and mentor students.

The appointee will join the BSRC, a highly collaborative environment that 
brings together scientists from Biology, Chemistry, Physics, and Medicine. It 
offers state-of-the-art infrastructure for enzymology and structural biology: 
instrumentation for protein expression and purification; dedicated radiation 
rooms for manipulation of radiolabelled substrates; phosphorimager for 
radioactivity assays; spectrophotometers, stopped-flow spectrofluorometer, and 
a quenched-flow for enzyme kinetics; microcalorimeters and CD spectrometers for 
thermodynamics; surface-plasmon resonance for ligand screening; 2 computer 
clusters with 292 cores and university-wide software licenses for computational 
chemistry; several NMR and MS spectrometers; and a full crystallography suite 
including incubators with UV/VIS light imager for 600 plates nL-scale 
crystallization trials and 007HF rotating anode X-ray generator outfitted with 
cryostream and Saturn 944+ CCD detectors for crystal diffraction, and access to 
Diamond Light Source. There is also a large critical mass in enzymology, 
structural biology, medicinal chemistry, and microbiology within the BSRC, with 
12 groups working in those areas.

Informal inquiries are encouraged and can be sent to Dr Clarissa Czekster 

Applications are particularly welcome from women, who are under-represented in 
Research posts at the University.

The University is committed to equality for all, demonstrated through our 
working on diversity awards (ECU Athena SWAN/Race Charters; Carer Positive; 
LGBT Charter; and Stonewall). More details can be found at 

Interview Date:  30 April to 2 May 2018

Please quote ref:  AR2058SB

Closing Date:  20 April 2018

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