Hi,
I am studying how HIV-1 Protease Inhibitors were developed so rapidly,
3-5 years vs. normal 10-15 years, enabling the HAART Drug Therapy to be
introduced in 1996? Can you suggest articles or contacts on how
/_cryocrystallography_/ (with synchrotrons) accelerated the first HIV
Protease Inhibitor development, employing Structure Based Drug Design.
In particular, how Macromolecular Cryo Crystallography accelerated the
introduction of the HIV Protease Inhibitors in 1996, which lead to the
Lazarus Effect, saving thousands of lives.These new Inhibitors were
essential in leading
to the successful introduction of the HAART HIV Drug Therapy.Any advice,
articles or knowledgeable-individuals relating to this topic would be
appreciated?
Email:[email protected] <mailto:[email protected]>
David Haas
Suffern NY
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