Dear all,
I’m looking for an enthusiastic PhD student to join my group at IGBMC
(http://www.igbmc.fr/research/department/3/team/134/), Strasbourg, France. We
are studying the structure and function of the dynein motor protein through an
integrated structural biology approach combining x-ray crystallography and
high-resolution cryoEM. The dynein motor is a complex and fascinating molecular
machine involved in essential cellular processes like mitosis, organelle
positioning and the beating of cilia
(https://www.ncbi.nlm.nih.gov/pubmed/24064538). We also have started to work
on the dynein motor related ribosome maturation factor Rea1
(https://www.ncbi.nlm.nih.gov/pubmed/30460895).
Applicants should possess a Master’s or Bachelor’s degree in the life
sciences, or a related discipline. The applicant should have experience in
molecular biology as well as protein expression and purification. Experience in
protein expression in yeast and/or insect cells would be considered an
advantage. Training in x-ray crystallography and cryoEM will be provided.
English language skills, the ability to work in a team, initiative, flexibility
as well as good organizational and learning skills are required.
The IGBMC (http://www.igbmc.fr/) is one of the leading biomedical research
institutions in Europe and provides regular synchrotron access as well as
cutting-edge cryo-EM facilities like a Titan Krios electron microscope equipped
with a Cs corrector, a GIF energy filter, a phase plate and a Gatan summit K2
direct electron detector. An ion beam scanning electron microscope
(cryo-FIB/SEM) and super-resolution fluorescence microscopy for cellular
tomography studies are also available.
Applicants should send a CV, a one-page summary of their research
experience and contact details for two referees till 15th January 2019 to
[email protected]. The starting date is spring 2019.
Selected publications:
Sosnowski P, Urnavicius L, Boland A, Fagiewicz R, Busselez, Papai G & Schmidt H
(2018) “The CryoEM structure of the Saccharomyces cerevisiae ribosome
maturation factor Rea1.” Elife. 2018 Nov 26;7. pii: e39163. doi:
10.7554/eLife.39163.
Schmidt H (2015) “Dynein motors: How AAA+ ring opening and closing
coordinates microtubule binding and linker movement.” Bioessays 37: 532-543.
Schmidt H, Zalyte R, Urnavicius L & Carter AP (2015) “Structure of human
cytoplasmic dynein-2 primed for its power stroke.” Nature 518: 435-438.
Schmidt H, Gleave ES & Carter AP (2012) “Insights into dynein motor domain
function from a 3.3-Å crystal structure” Nat Struct Mol Biol. 19:492-7.
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