Applications are invited for a PhD position, starting any time in 2019,
in the group Prof. Michael Hothorn at University of Geneva
(http://structplantbio.org). The lab combines structural biology (X-ray
protein crystallography, cryo electron microscopy) and quantitative
biochemistry with genetics and cell biology to dissect novel signal
transduction pathways required for plant growth and development. The
successful candidate will investigate how inositol pyrophosphate
signaling molecules involved in nutrient signaling interact with
different plant signaling proteins and protein complexes. She/he will
use state-of-the art molecular biology, protein biochemistry and
structural biology techniques to characterize these interactions in
molecular detail.
The candidate should have a first class degree in biochemistry or
closely related subject and ideally prior experience in molecular
biology and in protein biochemistry. A basic knowledge of protein
expression and purification, quantitative biochemistry, and in protein
crystallography or cryoEM would be highly appreciated.
Applications should be sent Prof. Michael Hothorn
([email protected]) as a single PDF document, containing a 2 page
CV (including details on the final grade or the expected grades) and a
motivational statement of up to 2 pages. Applicants should also include
contact details of 2-3 academic referees.
Informal inquiries can be addressed by email to Prof. Michael Hothorn
([email protected]). More information can be found here:
http://structplantbio.org
The successful candidate will receive an internally funded, full-time
PhD contract for up to 5 years.
_References_
Zhu J, Lau K, Harmel RK, Puschmann R, Broger L, Dutta AK, Jessen HJ,
Hothorn LA, Fiedler D, Hothorn M (2019) Two bifunctional inositol
pyrophosphate kinases/phosphatases control plant phosphate homeostasis.
bioRxiv doi: https://doi.org/10.1101/467076
Hohmann U, Nicolet J, Moretti A, Hothorn LA, Hothorn M (2018) The SERK3
elongated allele defines a role for BIR ectodomains in brassinosteroid
signalling. Nature Plants 4:345-351 doi: 10.1038/s41477-018-0150-9
Hohmann U, Santiago J, Nicolet J, Olsson V, Spiga FM, Hothorn LA,
Butenko MA, Hothorn M (2018) Mechanistic basis for the activation of
plant membrane receptor kinases by SERK-family coreceptors. PNAS
115(13):3488-3493
Wild R†, Gerasimaite R†, Jung JY†, Truffault V, Pavlovic I, Schmidt A,
Saiardi A, Jessen HJ, Poirier Y*, Hothorn M*, Mayer A* (2016) Control of
eukaryotic phosphate homeostasis by inositol polyphosphate sensor
domains. Science 352(6288):986-90
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