Post-doctoral/PhD position in the Chair of Applied Dynamics Friedrich-Alexander-Universität Erlangen-Nürnberg
The position is part of a DFG-funded project ‘A mechano-geometric framework to characterize macromolecular ensembles’ at the interface of robotics, structural bioinformatics and machine learning in collaboration with the Biosciences Division at SLAC National Accelerator Laboratory at Stanford University, and the Department of Bioengineering and Therapeutic Sciences at the University of California, San Francisco, California, USA. Experimental and computational advances have increasingly enabled atomically detailed insights into their structure and dynamics. However, the molecular mechanisms of protein function, and how those mechanisms are perturbed by (disease) mutations and ligand interactions remain poorly understood. In this project we will develop and apply efficient robotics-inspired computational methods to resolve and study molecular mechanisms, with a view to redirect protein function. This is a unique opportunity to join a world-class interdisciplinary research team with financial support for frequent travel between FAU and sunny California. The project focuses on aspects of • kinematic/geometric modeling of proteins/nucleic acids • optimized conformational sampling and motion planning/control • protein design, data-driven modeling, and machine learning • integrating crystallography, cryo-EM, and other data sources. • opportunities to gain bench experience The ideal candidate has obtained a MS degree (PhD preferred) in a quantitative discipline, like engineering, computational (bio-)physics or chemistry, applied mathematics, computer science, and an interest in structural biology. Proficiency in C++/Python, and fluency in English is required. Representative publications: Budday, Leyendecker, van den Bedem (2015) Geometric analysis characterizes molecular rigidity in generic and non-generic protein configurations. J. Mech. Phys. Solids 83:36-47 Budday, Leyendecker, van den Bedem (2018) Kinematic Flexibility Analysis: Hydrogen Bonding Patterns Impart a Spatial Hierarchy of Protein Motion. J. Chem. Inf. Model. 58:2108-2122 Dasgupta, Budday et al (2019) Cysteine modification can gate non-equilibrium conformational dynamics during enzyme catalysis. preprint at https://doi.org/10.1101/524751 For more information or to apply please contact: Sigrid Leyendecker ([email protected]) Henry van den Bedem ([email protected]) ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
