Dear Colleagues, An opportunity is available for a postdoctoral fellow to work with Jawdat Al-Bassam (http://microtubule.mcb.ucdavis.edu <http://microtubule.mcb.ucdavis.edu/>) at the Molecular Cellular Biology Department at the University of California at Davis. The Al-Bassam laboratory is focused on structural studies of assemblies regulating the biogenesis and polymerization of tubulin dimers and their impact on the polymerization of microtubules. The projects aim to characterize tubulin regulation by multi-subunit complexes using biochemical reconstitution, cryo-electron microscopy (cryo-EM) and x-ray crystallography. We have a particular interest in determining structures of multi-subunit complexes using well-developed tools in the laboratory, and then we aim to test functional mechanisms using in vitro reconstitution with dynamic microtubules. We are looking for an enthusiastic individual who thrives in a collaborative and supportive atmosphere. You should have a PhD in chemistry, biochemistry or biophysics and a desire to understand structures of multi-subunit macromolecular assemblies in relation to their functional mechanisms. Expertise required include molecular cloning, recombinant protein production using bacteria, insect and mammalian cells. The position would suit someone with a strong background in X-ray crystallography who also wants to learn cryo-EM, or someone who already has experience in cryo-EM and single particle image analysis. Please see our recent papers: https://elifesciences.org/articles/38922# <https://elifesciences.org/articles/38922#>, https://elifesciences.org/articles/08811 <https://elifesciences.org/articles/08811>.
The Al-Bassam laboratory has extensive tools and setups for protein production, biochemical characterization, x-ray crystallography in addition to computational resources. The laboratory has full access to a well-supported UC-Davis BIOEM facility, which includes cryo-EM sample preparation, a semi-automated side-entry JEOL 2100F microscope, and a new 200 KV Glacios microscope equipped with an autoloader and a K3 detector. UC-Davis is a member of the Bay Area Cryo-EM consortium with monthly access to Titan Krios microscopes for high resolution data collection. Please send any informal inquiries to [email protected] <mailto:[email protected]>. Please include a cover letter, CV, statement of research accomplishments, and two to three reference letters. To apply and access full details of the position please visit: http://microtubule.mcb.ucdavis.edu <http://microtubule.mcb.ucdavis.edu/> or https://recruit.ucdavis.edu/JPF02735 <https://recruit.ucdavis.edu/JPF02735> sincerely Jawdat M Al-Bassam Ph.D. Molecular Cellular Biology University of California Davis ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
