I remember from biochemistry class that it’s the one element that has no known physiological role—is that still true?
JPK +++++++++++++++++++++++++++++++++++++++++++++++++ Jacob Pearson Keller Research Scientist / Looger Lab HHMI Janelia Research Campus 19700 Helix Dr, Ashburn, VA 20147 Desk: (571)209-4000 x3159 Cell: (301)592-7004 +++++++++++++++++++++++++++++++++++++++++++++++++ The content of this email is confidential and intended for the recipient specified in message only. It is strictly forbidden to share any part of this message with any third party, without a written consent of the sender. If you received this message by mistake, please reply to this message and follow with its deletion, so that we can ensure such a mistake does not occur in the future. From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK> On Behalf Of Aaron Finke Sent: Tuesday, April 2, 2019 11:21 AM To: CCP4BB@JISCMAIL.AC.UK Subject: Re: [ccp4bb] beryllium chloride The lung disease is called berylliosis and is an allergic-type response that leads to fibrosis in the lungs. A significant percentage of the population has allergic reactions to beryllium, but there is no very accurate method for prescreening this; I read somewhere even lung biopsies are only about 80% accurate for beryllium sensitivity. Beryllium metal readily oxidizes in air and BeO is the typical inhlation vector. Mind you, this is on top of the carginogenic properties of beryllium and its compounds. It’s just nasty stuff. Shame it’s so useful... Aaron ------------------------------------------ Aaron Finke Staff Scientist, MacCHESS Cornell University e-mail: af...@cornell.edu<mailto:af...@cornell.edu> On Apr 2, 2019, at 10:21 AM, Zhijie Li <zhijie...@utoronto.ca<mailto:zhijie...@utoronto.ca>> wrote: Sometime ago when I was watching a Youtube video on magnetron I learnt that at least at at certain point of time the antenna port of the magnetron was sealed using beryllium oxide ceramic(probably for its high thermal conductivity). The video maker warned that this ceramic was extremely dangerous. Further wikipedia and internet reading confirmed that fine beryllium oxide powder does cause something called beryllium disease and cancer (the latter in a way similar to that of asbestos? I guessed). However the sintered ceramic form is probably as safe as emerald unless you have to grind it and breath the dust every day. (I think most jewellers would always use some grinding liquid when honing their stones.) The wikipedia page on beryllium oxide has some really interesting facts. Also if one is desperate for some beryllium salt it hints dissolving a magnetron antenna sealing ring in hot concentrated solution of H2SO4 and (NH4)2SO4. My 2 cents. Zhijie On Apr 2, 2019, at 8:39 AM, Ian Tickle <ianj...@gmail.com<mailto:ianj...@gmail.com>> wrote: Yes both soluble beryllium salts and powdered beryllium metal even applied to the skin are known to cause sensitization and is a route into the bloodstream where it is highly carcinogenic (I am not speaking from experience!). Yet strangely the one source of beryllium that many people (at least the more well-off among us) commonly come into contact with, namely the gemstone emerald Be3Al2(SiO3)6 obviously has no known toxic effects whatosever! Apparently even gemstone grinders show no ill effects! I guess it's the free Be2+ ion that's so toxic. Cheers -- Ian On Tue, 2 Apr 2019 at 13:07, Aaron Finke <af...@cornell.edu<mailto:af...@cornell.edu>> wrote: 1. Yes, I meant the tetrahydrate, [Be(H2O)4]2+ 2Cl- 2. Bob, I studied that page, and couldn’t get past BeCl2 is known to have a “sweetish taste.” I’m very glad chemists no longer characterize chemicals by their taste anymore... ------------------------------------------ Aaron Finke Staff Scientist, MacCHESS Cornell University e-mail: af...@cornell.edu<mailto:af...@cornell.edu> On Apr 1, 2019, at 22:37, Sweet, Robert <000027e0eb9d20ec-dmarc-requ...@jiscmail.ac.uk<mailto:000027e0eb9d20ec-dmarc-requ...@jiscmail.ac.uk>> wrote: With all respect, this conversation make my skin crawl a little. I've been taught that beryllium salts are EXTREMELY toxic. Please study this: https://pubchem.ncbi.nlm.nih.gov/compound/beryllium_chloride Hopefully, Bob ================================================ Robert M. Sweet E-Dress: sw...@bnl.gov<mailto:sw...@bnl.gov> Deputy Director, LSBR: The Life Science and Biomedical Technology Research Center at NSLS-II Photon Sciences and Biology Dept Brookhaven Nat'l Lab. Upton, NY 11973 U.S.A. Phones: 631 344 3401 (Office) 631 338 7302 (Mobile) ================================================ ________________________________ From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>> on behalf of Diana Tomchick <diana.tomch...@utsouthwestern.edu<mailto:diana.tomch...@utsouthwestern.edu>> Sent: Monday, April 1, 2019 7:03 PM To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: Re: [ccp4bb] beryllium chloride No, that should read <Screen Shot 2019-04-01 at 6.03.07 PM.png> Diana ************************************************** Diana R. Tomchick Professor Departments of Biophysics and Biochemistry UT Southwestern Medical Center 5323 Harry Hines Blvd. Rm. ND10.214A Dallas, TX 75390-8816 diana.tomch...@utsouthwestern.edu<mailto:diana.tomch...@utsouthwestern.edu> (214) 645-6383 (phone) (214) 645-6353 (fax) On Apr 1, 2019, at 5:54 PM, Keller, Jacob <kell...@janelia.hhmi.org<mailto:kell...@janelia.hhmi.org>> wrote: Is that 4+ an April fools’ joke? Pretty crazy if not…can’t think of another ion with such a charge, well except things like DNA and proteins, but not single atoms. JPK +++++++++++++++++++++++++++++++++++++++++++++++++ Jacob Pearson Keller Research Scientist / Looger Lab HHMI Janelia Research Campus 19700 Helix Dr, Ashburn, VA 20147 Desk: (571)209-4000 x3159 Cell: (301)592-7004 +++++++++++++++++++++++++++++++++++++++++++++++++ The content of this email is confidential and intended for the recipient specified in message only. It is strictly forbidden to share any part of this message with any third party, without a written consent of the sender. If you received this message by mistake, please reply to this message and follow with its deletion, so that we can ensure such a mistake does not occur in the future. From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>> On Behalf Of Aaron Finke Sent: Monday, April 1, 2019 6:45 PM To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: Re: [ccp4bb] beryllium chloride American Elements sells BeCl2 but you’d have to check with them on what scale they sell it at. They tend to do custom manufacturing. https://www.americanelements.com/beryllium-chloride-7787-47-5 BeCl2 dissociates in aqueous solution to form Be(H2O)4+ 2Cl-. Aaron ------------------------------------------ Aaron Finke Staff Scientist, MacCHESS Cornell University e-mail: af...@cornell.edu<mailto:af...@cornell.edu> On Apr 1, 2019, at 17:07, Alexandra Deaconescu <alexandra_deacone...@brown.edu<mailto:alexandra_deacone...@brown.edu>> wrote: Hello, Is anyone aware of a company that sells Beryllium chloride in the US? Sigma does not carry it any longer, and a quick Google search failed to reveal alternatives. Thank you very much, Alexandra -- Alexandra Deaconescu, B.E., Ph.D. Assistant Professor Brown University Office: (401) 863-3215 Wet Lab: (401) 863-6729 Computational Lab: (401) 863-7031 For Mail: Laboratories of Molecular Medicine 70 Ship St. GE-4 Providence, RI 02903 For Courier: Laboratories of Molecular Medicine Brown University 70 Ship St., Chestnut St. Loading Dock Providence, RI 02903 Website: www.deaconesculab.com<http://www.deaconesculab.com/> Admin Ms. Christina Fournier Email: christina_fournier[at]brown.edu<http://brown.edu/> Mailing Address: Box G-E, Brown University, Providence, RI 02912-G Telephone: 401-863-2782 Confidentiality Notice: This e-mail message, including any attachments, is for the sole use of the intended recipient(s) and may contain confidential, proprietary and privileged information. Any unauthorized review, use, disclosure or distribution is prohibited. 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