Dear all, What is more preferable or conserved by evolution of lifeform point of view between glutamate acting as bidentate ligand by its carboxylate group or two monodentate GLU at metal binding site in natural metalloenzymes. I was thinking 2 GLU are better than one bidentate GLU because if one GLU gets mutated other GLU will still be able to form a coordination bond to a metal. Please comment and help if i am right or wrong. metal is Fe2+. In short which will evolve with time a bidentate GLU or 2 monodentate GLU.
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