I take it that the datasets are from different crystals. Are the 
crystallisation conditions the same? I can't spot any signs of a difference in 
indexing (but I may be wrong) so they look like different crystal forms. Are 
the processing statistics good for both? Is this a case for molecular 
replacement or experimental phasing? You could work with best diffracting one 
and solve that one first and then use it to solve the other by molecular 
replacement. Hope some of this helps.

Sent from Yahoo Mail on Android 
 
  On Sun, 8 Sep 2019 at 12:16, Prerana G.<[email protected]> wrote:   Dear all,

We have two data sets of a protein with the following parameters:1. Space group 
P212121 a=61.0, b=100.34, c=133.23 No. of molecules in ASU - 2
2. Space group P212121 a=58.33, b=62.86, c=109.45 No. of molecules in ASU - 1
Can we use them as two different structures?
Regards,Prerana


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