Pyruvate kinase specially M2 isoform is one example which exists in tetramer 
and dimer/monomer state. Several ligands affect its shape and oligomeric state, 
thus affecting its activity.

Dhiraj
________________________________
From: CCP4 bulletin board <[email protected]> on behalf of Gabriela GARCIA 
RODRIGUEZ <[email protected]>
Sent: Wednesday, October 9, 2019 6:14 AM
To: [email protected] <[email protected]>
Subject: [ccp4bb] Changes in quaternary structure

Dear CCP4BB subscribers,

I am writing a discussion on extensive quaternary changes between two different 
homodimers of the same protein and I would like to ask you for any examples of 
your own work/that you know of to include in my analysis. Basically, any 
proteins known to exist in two different (or more) homodimerised states 
(suffering changes in domain organisation between states would be even more 
interesting).
I would greatly appreciate any examples! Thank you for your time and attention.

Warm regards,

Gabriela
____

Gabriela Garcia Rodriguez

[email protected]<mailto:[email protected]>

PhD candidate

Structural Biology Research Centre (SBRC)

Vlaams Instituut voor Biotechnologie (VIB) - Vrije Universiteit Brussel (VUB)

Pleinlaan 2- 1050 Brussels, Belgium






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