Postdoctoral Research Fellow in Protein Crystallography
A postdoctoral scientist is required to join a well-established MRC funded research group studying bacterial quorum sensing proteins. The project will explore the structure and biochemistry of the Agr system in a collaboration between the groups of Jonas Emsley and Paul Williams (microbiology). In Staph. aureus, the agr quorum sensing system regulates virulence, intracellular survival and biofilm development and is conserved in other staphylococcal species as well Listeria, Enterococcus and Clostridium. For each of these pathogens, the key agr components are an autoinducing peptide (AIP) signal molecule and a two component sensor regulator system. AIPs generated from an AgrD pro-peptide via AgrB are exported and subsequently sensed via a sensor kinase (AgrC) on neighbouring cells and regulator AgrA. The purpose of the role is to determine the crystal structures from the Agr system. State-of-the-art facilities in the crystallography lab includes nanolitre dispensing crystallisation robotics, crystal imaging system and a modern high flux rotating anode X-ray data collection system and Diamond synchrotron access. These labs are housed in the Centre for Biomolecular Sciences located on the University of Nottingham main campus. The Centre for Biomolecular Sciences is a vibrant interdisciplinary research environment with many biophysical, imaging and computing resources available for collaborative research. Candidates must have a PhD in protein crystallography and experience in X-ray crystallography. Experience in molecular biology, soluble protein and membrane protein expression and purification/crystallisation is highly desirable. Salary will depend on qualifications and experience. This post is available Jan 2020 and will be offered on a fixed-term contract for a period of 1 year. Informal enquiries may be addressed to Dr J Emsley Email: [email protected]<mailto:[email protected]>. Job Ref : SCI436919 Job Title : Research Associate/Fellow in Protein Crystallography (fixed term 12 months) ################################## Dr Jonas Emsley Professor of Macromolecular Crystallography, Centre for Biomolecular Sciences, School of Pharmacy, University of Nottingham, University Park, Nottingham. NG72RD Tel: +44 1158467092 Fax: +44 1158468002 email:[email protected]<mailto:[email protected]> http://www.nottingham.ac.uk/research/groups/structural-biology/index.aspx This message and any attachment are intended solely for the addressee and may contain confidential information. If you have received this message in error, please contact the sender and delete the email and attachment. Any views or opinions expressed by the author of this email do not necessarily reflect the views of the University of Nottingham. Email communications with the University of Nottingham may be monitored where permitted by law. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
