IMPACT: MRC Funded Doctoral Training Partnership PhD Project Available Deconstructing the Role of the MOZ/KAT6A Double Winged Helix Domain in Gene Regulation and Disease
Professor David M Heery University of Nottingham Dr Ralf Flaig Diamond Light Source, Research Complex at Harwell Dr Ingrid Dreveny University of Nottingham A PhD project (MRC Impact funded) is available in the Gene Regulation & RNA Biology Laboratory, University of Nottingham under the supervision of Professor David M Heery. The project will involve a structure/ function characterisation of a novel domain within the gene regulatory protein KAT6A/ MOZ. Mutations in this gene are associated with childhood leukemias and neurodevelopmental syndromes. KAT6A/ MOZ has multiple functions, one of which is an epigenetic regulator controlling histone acetylation. Our long-term aim is to understand the role of a double winged helix domain in the pathology of these conditions. The project will provide the opportunity to learn a range of molecular and cell biology techniques including protein purification/ crystallisation, DNA binding assays, site-directed mutagenesis and CRISPR CAS9 editing. The project involves a collaboration with Dr Ingrid Dreveny (Structural Biology) and Dr Ralf Flaig at Diamond Light Source/ Research Complex Harwell. For further information and details on how to apply please contact [email protected] Please note, IMPACT studentships are available to UK and EU nationals ONLY. For full details on eligibility, and the application process please refer to https://more.bham.ac.uk/mrc-impact/phd-opportunities/ https://www.findaphd.com/phds/project/deconstructing-the-role-of-the-moz-kat6a-double-winged-helix-domain-in-gene-regulation-and-disease/?p116979 The application deadline is 5.00pm Friday 17 January 2020. Interviews will take place the week commencing 17 February 2020. -- Dr. Ralf Flaig [email protected] Principal Beamline Scientist, I04 Macromolecular Crystallography Diamond Light Source, Harwell Science and Innovation Campus Chilton, Didcot OX11 0DE, United Kingdom tel: +44 (0)1235 77 8412 fax: +44 (0)1235 77 8448 http://www.diamond.ac.uk/mx-home/ -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. Diamond Light Source Ltd. cannot guarantee that this e-mail or any attachments are free from viruses and we cannot accept liability for any damage which you may sustain as a result of software viruses which may be transmitted in or with the message. Diamond Light Source Limited (company no. 4375679). Registered in England and Wales with its registered office at Diamond House, Harwell Science and Innovation Campus, Didcot, Oxfordshire, OX11 0DE, United Kingdom ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
