I think you’re asking if two proteins with the same fold can have different activities.
As was previously mentioned, this is quite common. The best characterized example is the TIM barrel fold - such proteins can be isomerases, transferases, hydrolases, lyases, or oxidoreductases, to name a few... ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1