WANTED: 2 experienced Postdocs This project will explore Nanobody binding to the human norovirus capsid protein using a combination of X-ray crystallography and cryo-EM. These Nanobodies are expected to work as potential antivirals and could lead into clinical trials if successful. A massive library of Nanobodies are ready to be tested ;)
See: https://www.dkfz.de/en/noroviren/index.php Previous studies: *Nanobodies targeting norovirus capsid reveal functional epitopes and potential mechanisms of neutralization. PLoS Pathog. 2017 Nov 2;13(11):e1006636. *Nanobody binding to a conserved epitope promotes norovirus particle disassembly. J Virol. 2015 Mar;89(5):2718-30. Our lab is fully equipped to carryout all experiments and we have plenty of beamline access. Furthermore, a collaboration (including travel and research stays) with an Australian partner is also possible (Gold Coast/ Queensland). Two qualified Postdocs with experience in solving and refining X-ray structures are urgently needed. Email: [email protected] ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
