Hello,

I haven't seen this before but doing a round of refinment with REFMAC, after 
molecular replacement with phaser, my R factor and R free have increased?

Also is it weird that my Rfree is smaller than my R factor?


Result:

Initial Final
R factor        0.3621  0.3761
R free  0.3108  0.4733
Rms BondLength  0.0076  0.0057
Rms BondAngle   1.6504  1.5193
Rms ChirVolume  0.0600  0.0526
My map was ok(ish) but there was indication of anistropy so I attempted to 
improve it by using STARANISO and re-ran phaser with the output, and this is 
the results I see following REFMAC.

Thanks,

Kyle

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