Structural dynamics of light-sensitive proteins studied
by time-resolved crystallography at XFELs
We have an opening for a PhD student at the /Institut de Biologie
Structurale/ (www.ibs.fr <http://www.ibs.fr>) in Grenoble, France, to
study the structural dynamics of light-sensitive proteins by
time-resolved serial crystallography at XFELs and potentially future
4^th generation synchrotrons.
Serial femtosecond crystallography (SFX) at X-ray free electron lasers
(XFEL) allows studying crystalline proteins /at work/ by means of
time-resolved crystallography (TR-SFX). We apply TR-SFX to explore
conformational changes after photon absorption by various
light-sensitive proteins on a broad time scale ranging from
sub-picoseconds to seconds (Nature Chemistry 10, 31 (2018); Nature
Communications 11, 741 (2020)). These animate structures obtained by
static SFX (J Phys Chem Lett 7, 882 (2016); Nature 539, 43 (2016)).
Experiments are being carried out at the XFELs in Hamburg (EuXFEL), in
Japan (SACLA), at Stanford (LCLS), in Switzerland (SwissFEL) and are
planned to take place at the newly upgraded ESRF synchrotron.
For details on our research and collaborators, see:
http://www.ibs.fr/research/research-groups/dynamics-and-kinetics-of-molecular-processes-group-m-weik/structural-protein-dynamics/
http://www.ibs.fr/research/research-groups/dynamics-and-kinetics-of-molecular-processes-group-m-weik/snax/
We welcome applications from students trained in protein biophysics, and
preferably in crystallography.
If you are interested, please contact either Martin Weik ([email protected]
<mailto:[email protected]>) or Jacques-Philippe Colletier ([email protected]).
--
Martin Weik
Structural Protein Dynamics Research Team
Institut de Biologie Structurale
CAMPUS EPN
71 avenue des Martyrs
CS10090
38044 Grenoble Cedex 9; France
Phone: (33) 4 57 42 85 80
email: [email protected]
http://www.ibs.fr/groups/dynamics-and-kinetics-of-molecular/structural-protein-dynamics/?lang=en
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