Dear Vito,
Could you precise in what kind of maps are you experiencing these effects:
2FoFc refinement maps or experimental phasing ?
I had this kind of effects long ago in experiemental phasing due to Fourier
transform ripple effects. This could be due to scaling problems, low resolution
truncation or incompletness (maybe intensity overloads).
Another source condition could be local X-ray dose degradation due to the high
absoption of the metals.
Best regards,
Pierre Legrand
PROXIMA-1, SOLEIL
________________________________________
De : CCP4 bulletin board [[email protected]] de la part de Vito Calderone
[[email protected]]
Envoyé : mercredi 10 juin 2020 08:42
À : [email protected]
Objet : [ccp4bb] Heavy atom vs light atoms density
Dear All,
many of us have probably experienced that, in the diffraction of
protein ligands containing heavy atoms (cisPt, I3C, etc), the overwhelming
electron density of the metal can totally flatten that of the light atoms
around (or rather make it look insignificant).
Is anyone aware of an article/review (to use as a reference) in which this is
clearly stated/pointed out?
Best regards
Vito Calderone
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