Dear Herman

Thank you - perfect!
Never had to click that before!

Susan

Prof Susan M. Lea
Professor of Microbiology
Wellcome Trust Investigator
Sir William Dunn School of Pathology, Oxford, OX1 3RE
T: +44 1865 275181
Professorial Fellow @ Wadham College, Oxford

On 27 Aug 2020, at 13:34, Schreuder, Herman /DE 
<[email protected]<mailto:[email protected]>> wrote:

Dear Lea,

when doing real space refinement in coot, on has to change the refinement 
weight, otherwise that map gets way to much weight and the coordinates get 
squeezed into to the density with the result you show. The way to do this is to 
click on the R/RC button (in my case in the upper right corner of the coot 
window) and then click on the estimate button behind the refinement weight.

Best regards,
Herman

Von: CCP4 bulletin board <[email protected]<mailto:[email protected]>> 
Im Auftrag von Susan Lea
Gesendet: Donnerstag, 27. August 2020 13:42
An: [email protected]<mailto:[email protected]>
Betreff: [EXTERNAL] [ccp4bb] Error in coot post-refine in Phenix


EXTERNAL : Real sender is 
[email protected]<mailto:[email protected]>

Has anyone else run into this problem? Using Phenix (nightly download of  a few 
days ago) for real space refinement of coordinates against a cryoEM map all 
looks good until
I try and fit a small region in coot 0.9EL  when, post-fit, end up with bonds 
being drawn between all clost atoms and chemistry is screwed up (see picture 
below).
Atoms names etc look OK on first glance. Not sure if this is a Coot or Phenix 
problem! Same issue with both .pdb and .cif versions of the coordinates.

Susan

<image001.png>
Prof Susan M. Lea
Professor of Microbiology
Wellcome Trust Investigator
Sir William Dunn School of Pathology, Oxford, OX1 3RE
T: +44 1865 275181
Professorial Fellow @ Wadham College, Oxford


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