As part of a suite of workshops during the SSRL/LCLS Annual Users’ Meeting, members of the SSRL Structural Molecular Biology group are co-hosting two exciting workshops on Metals in Structural Biology and X-ray Science Applications for COVID-19 Research.
There is no cost for these workshops but you must register for the free SSRL/LCLS Users’ Meeting by 5 PM PDT, September 25 2020. Please register at: https://events.bizzabo.com/SLAC-UsersMeeting-2020 SSRL/LCLS Users’ Meeting Workshop: Metals in Structural Biology I September 28-29, 2020 8:00 am – 1:00 pm (PDT) - same time on both days Metals play critical roles in biology, conferring unique reactivity, enabling challenging chemistry and redox reactions, and functioning as structural scaffolds. It has been estimated that 30-50% of all proteins bind a metal or metal cofactor. Synchrotron-based techniques enable experiments that measure and monitor metal active site geometry and protein structure, as well as permitting elemental analysis to probe exactly what metals are present in a sample. In the Metals in Structural Biology workshop we will emphasize the use of spectroscopic, X-ray crystallography, XFEL, and cryo-EM methods to study metalloprotein structure and function. Agenda (September 28) - Elspeth Garman, University of Oxford: Introduction: High throughput micro-PIXE: an essential tool for metalloprotein research - Kenny Kang, Wellesley College: Caught in the act: Visualizing the holocomplex of E. coli ribonucleotide reductase - Jocelyn Richardson, SLAC National Accelerator Laboratory/SSRL: Chemical imaging at SSRL: Biological and Environmental Applications - Kelly Summers, University of Saskatchewan: Synchrotron Hard X-Ray Spectroscopy and Imaging Techniques in the Study of Alzheimer's Disease - Chae Un Kim, Ulsan National Institute of Science and Technology: Role of Metal Ions in Carbonic Anhydrase Catalysis - David Barondeau, Texas A&M University: Architectural swapping activation mechanism for the human Fe-S cluster assembly complex - Remembrance of Deborah Zamble Agenda (September 29) - Panel Discussion Panelists Doug Rees, California Institute of Technology Allen Orville, Diamond Lightsource Liliana Quintanar, Cinvestav Kelly Chacon, Reed College John Bacik, Cornell University Organizers: Sarah Bowman, Hauptman Woodward Institute Jennifer Bridwell-Rabb, University of Michigan Jeney Wierman, SLAC National Accelerator Laboratory/SSRL SSRL/LCLS Users’ Meeting Workshop: X-ray Science Applications for COVID-19 Research October 7, 2020 8:00 am – 12:00 pm (PDT) During the COVID pandemic in March 2020, SSRL resumed operations, under a minimum operations mode, to support critical COVID-19 related research. This session will highlight some recent results that employed X-ray light source facilities to further our understanding COVID-19 and aid in the search for an effective vaccine or other treatments. Agenda - Aina Cohen, SLAC National Accelerator Laboratory/SSRL: Introduction: Support of COVID-19 research at SSRL - Ian Wilson, The Scripps Research Institute: Structural evaluation of the neutralizing antibody response to SARS CoV-2 - M. Joanne Lemieux, University of Alberta: Structural insights into the feline coronavirus drug GC376, which inhibits the main protease of SARS-CoV-2 and blocks virus replication - Christopher Barnes, California Institute of Technology: Structures of human antibodies bound to the SARS-CoV-2 spike glycoprotein define correlates of antibody-mediated neutralization - Benjamin Bostick, Columbia University: Covid-19 quarantine related changes in particulate matter source and speciation - Gerard Wong, University of California, Los Angeles: Molecular biomimicry of the SARS-CoV-2 virus and consequences for severe inflammation - James Fraser, University of California, San Francisco: Finding ligands for the Nsp3 macrodomain of SARS-CoV-2? Organizers: Aina Cohen, SLAC National Accelerator Laboratory/SSRL Clyde Smith, SLAC National Accelerator Laboratory/SSRL ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
