Assuming that there are no bad van der Waals contacts, there should not be a problem. All the hydrophilic residues in your loop have hydrophobic parts which the methionine can interact with favourably. This should send any nearby waters into the more disordered bulk phase, which is entropically favourable, if you believe the traditional hydrophobic effect theory (although there was never much evidence for it, afaik). For your loop, it's more a question of whether the charged groups have sufficient solvent accessibility or can interact with each other enough for the conformation to be stable. Hope this helps a bit.
Best wishes, Jon Cooper. [email protected] -------- Original Message -------- On 25 Oct 2020, 20:54, amit gaur wrote: > Hi All, > I have a question that, I have a loop region with hydrophilic > residues(TNETRERE) that lie close to methionine. Can, repulsive forces may > occur because between methionine and hydrophilic residues? > > -- > > Dr. Amit Gaur > Post Doctoral Researcher > Thomas Jefferson University > > --------------------------------------------------------------- > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
