Dear all,

Leicester Institute of Structural and Chemical Biology (LISCB) are proud to 
present six exciting, beautifully-produced short films designed to reach out to 
industry partners and other stakeholders. We hope you view these as the 
“front-cover” to a longer story with our academics.

We previously would welcome Industry collaborators, old and new, to our Bench 
to Business industry open days at the Henry Wellcome Building in Leicester, 
however, in these challenging times, we found an innovative and entertaining 
way to bring the scientists to industry.

The production of these films was made as part of the University of Leicester’s 
Industry Academia Exchange (IAX) platform, which is funded by the MRC Proximity 
to Discovery fund.

Five shorts show our scientists outlining their work of either a novel target – 
including validation, assay development, structural insights and ligand 
discovery; or development of novel chemical entities with proof of concept 
against exemplar targets.  This information is blended with high quality 3D CGI 
to make a compelling visual whole. A last film takes the viewer on a virtual 
tour of our unique structural and chemical biology facilities, and we welcome 
industrial users to get in touch about what services or research we can provide 
to aid their drug discovery programmes.

LISCB Business Development Manager, Dr Charlotte Walden says “We hope you will 
spend just a few minutes enjoying our films to learn of our cutting edge 
technologies and next generation targets. They are designed to be a summary of 
a translational application, from which we hope to have further discussions 
with you.”

All films can be accessed here:
https://www.youtube.com/playlist?list=PLkBZZhQeuA82ygmWIpmOlSBfTDCcxED_F

or individually:

Facilities Tour introducing our comprehensive and cutting-edge facilities: Cryo 
EM, X-ray crystallography, NMR, single-molecule techniques, computation and 
biological chemistry. https://www.youtube.com/watch?v=Ww-pACFWvLE

Cyril Dominguez is targeting splicing factors in the discovery of novel 
therapeutics for complex diseases
https://www.youtube.com/watch?v=ruYGmC9jfrs


Richard Doveston is developing molecular glue design and discovery strategies 
and explores stabilisation of 14-3-3 proteins for tumour suppression 
https://www.youtube.com/watch?v=5nK7hWesUf8


Joanna Fox is potentiating apoptosis through activation of BAK for the 
treatment of cancer. https://www.youtube.com/watch?v=ytVjPh10hWc


Bibek Gooptu has identified the Gal-3 fibrosome as a target in lung fibrosis 
and inflammation https://www.youtube.com/watch?v=PXfZr1KXjP8

James Hodgkinson and colleagues have developed PROTAC degraders of histone 
deacetylase enzymes   https://www.youtube.com/watch?v=kYi21aFrR2U



kind regards,
Tennie


Dr Tennie Videler
LISCB manager
Leicester Institute of Structural and Chemical Biology
Office 025 Henry Wellcome Building
University of Leicester  LE1 7HB
for now: 07850-996863

LISCB website: https://le.ac.uk/liscb
Twitter: @LeicStructBio<https://twitter.com/LeicStructBio>



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