Dear all Gentle reminder about the deadline of tonight for statements of support for two MX beamline projects at Diamond Light Source as part of the Diamond II upgrade programme:
* A major upgrade (KMX) of I24 will enhance its microfocus capability and extend further its serial synchrotron crystallography offering. The KMX proposal outline can be found here<https://www.diamond.ac.uk/dam/jcr:add3277b-5bc2-4e8b-93a2-25d1e0e585f6/MX%20-%20I24%20KMX:%20kinetics%20and%20microfocus%20upgrade.pdf> * The I04-1 XChem beamline will be rebuilt as K04 to make a step-change in its XChem fragment screening programme. The K04 proposal outline can be found here<https://www.diamond.ac.uk/dam/jcr:bd879384-900b-4a2c-897d-a8e0e818c6e8/MX%20-%20I04-1%20XChem%20reinvention%20as%20K04%20XChem.pdf> . There are 11 other projects under consideration and only 5 can be funded and community support is an essential part of the review process. If you see a need in the future for either or both of these proposals to be key to your research then please complete the short webform here<https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u>. Deadline for submission is by 23:59 GMT today (Tuesday 24th November). Click here<https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u> to register support. Thanks Dave From: "ccp4bb@jiscmail.ac.uk" <CCP4BB@JISCMAIL.AC.UK> on behalf of "david.h...@diamond.ac.uk" <david.h...@diamond.ac.uk> Reply to: "david.h...@diamond.ac.uk" <david.h...@diamond.ac.uk> Date: Thursday, 19 November 2020 at 08:53 To: "ccp4bb@jiscmail.ac.uk" <CCP4BB@JISCMAIL.AC.UK> Subject: Re: [ccp4bb] Diamond-II MX beamlines letters of support Dear all To follow up on Dave and Arnaud’s email (thanks!) the deadline for submissions of statements of support has been extended to 23:59 (GMT) on Tuesday 24th November. There are fantastic proposals across the life and physical sciences for flagship projects for the Diamond II upgrade and statements of support from the community alongside the science cases developed with the user working groups are an important part of the review process. Support statements from our many past, current and future users and supporters of the two flagship MX beamline projects outlined below would be greatly appreciated. You can be from the future generation of structural biologists through to PIs, HoDs, etc from both academia and industry and can submit support both as an individual and/or representing your organisation (Dept, University, DTP, company, etc) as appropriate. Your support will help us shape the future science you can do at Diamond. Statements of support can be submitted via this link<https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u>. Many thanks Dave Hall MX Group Leader Diamond Light Source From: "ccp4bb@jiscmail.ac.uk" <CCP4BB@JISCMAIL.AC.UK> on behalf of David Briggs <david.bri...@crick.ac.uk> Reply to: David Briggs <david.bri...@crick.ac.uk> Date: Wednesday, 18 November 2020 at 10:10 To: "ccp4bb@jiscmail.ac.uk" <CCP4BB@JISCMAIL.AC.UK> Subject: [ccp4bb] Diamond-II MX beamlines letters of support Dear all, (Apologies for the slightly off-topic cross-post - hopefully, this will be of interest to all MX practitioners, not just Diamond light source users.) As Diamond User Committee MX representatives, we'd just like to remind you that the deadline for letters of support for Diamond-II beamline upgrades is this Friday, 20th November. As you are perhaps aware, the Diamond machine is scheduled for a major upgrade to a 4th generation source 2025-2027. Further information about the upgrade can be found here<https://www.diamond.ac.uk/Home/About/Vision/Diamond-II.html>. All MX beamlines will benefit from a brighter, more focused source – however, two MX beamlines have been selected as flagship projects for significant upgrades. I04-1 > K04 Ultra XChem. The I04-1 fixed wavelength beamline used for the XChem fragment screening will be completely rebuilt as K04. Briefly, K04 will allow higher throughput fragment screening (meaning more projects and more fragments can be screened) and it is hoped the improved characteristics of the Diamond-II beam will allow XChem methodologies to be extended to more difficult targets such as transmembrane proteins. The K04 proposal outline can be found here<https://www.diamond.ac.uk/dam/jcr:bd879384-900b-4a2c-897d-a8e0e818c6e8/MX%20-%20I04-1%20XChem%20reinvention%20as%20K04%20XChem.pdf> [PDF]. I24 > KMX Kinetic micro crystallography. The I24 microfocus beamline will be upgraded to enhance the capabilities of I24 and allowing analysis of smaller crystals, radiation-sensitive crystals, and expanding the serial synchrotron crystallography (SSX) functionality of the beamline. The abilities to conduct room temperature SSX will also be enhanced to allow in-crystal kinetic analysis, with various on-line spectroscopic (Raman, UV-Vis, XES) detectors built into the end station. The KMX proposal outline can be found here<https://www.diamond.ac.uk/dam/jcr:add3277b-5bc2-4e8b-93a2-25d1e0e585f6/MX%20-%20I24%20KMX:%20kinetics%20and%20microfocus%20upgrade.pdf> [PDF] Having read these proposals you will obviously be very excited by the possibilities and will want to submit your letters of support for both of them, by Friday, 20th November Letters of support can be submitted via this link<https://forms.office.com/Pages/ResponsePage.aspx?id=dLonnQABDU2B_x1yja6N9sORn9fQKRxBrdwp3-jvXxFURTZRTU9VM1I2VVZEVEVFS1hJTlNHUThISi4u>. Thanks in advance, Dave & Arnaud. -- Dr David C. Briggs Senior Laboratory Research Scientist Signalling and Structural Biology Lab The Francis Crick Institute London, UK == Diamond User Committee MX representative == about.me/david_briggs The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT -- This e-mail and any attachments may contain confidential, copyright and or privileged material, and are for the use of the intended addressee only. If you are not the intended addressee or an authorised recipient of the addressee please notify us of receipt by returning the e-mail and do not use, copy, retain, distribute or disclose the information in or attached to the e-mail. Any opinions expressed within this e-mail are those of the individual and not necessarily of Diamond Light Source Ltd. 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