The Institute of Cancer Research (ICR), London, is one of the world’s most influential cancer research institutes, with an outstanding record of achievement dating back more than 100 years. Under the leadership of our Chief Executive, Professor Paul Workman FMedSci, the ICR is ranked as the UK’s leading academic research centre. Together with our partner The Royal Marsden Hospital, we are rated in the top four cancer centres globally. The ICR is committed to attracting, developing and retaining the best minds in the world to join us in our mission – to make the discoveries that defeat cancer.
The Cancer Research UK Cancer Therapeutics Unit (CTU), within the Division of Cancer Therapeutics, is a multidisciplinary 'bench to bedside' centre, comprising around 160 staff dedicated to the discovery and development of novel therapeutics for the treatment of cancer. The CTU’s exciting goal is to discover high quality small molecule drug candidates and to progress these to clinical trial. All the scientific disciplines are in place to make this possible, including medicinal chemistry, biology, structural biology, assay scientists, drug metabolism and clinical specialists. A postdoctoral position is available in Dr Rob van Montfort’s Hit Discovery and Structural Design Team within the CTU in Sutton. The Post-doc will be involved in the structure determination of protein complexes by cryo-electron microscopy (cryoEM) as part of CTU research programmes in targeted protein degradation. The postholder will be responsible for sample preparation, structure determination by cryoEM, and subsequent structural analysis of protein complexes and will interact closely with the structural biologists and biology, computational chemistry and medicinal chemistry teams at the CTU. The successful candidate will also be part of the Division of Structural Biology, located in Chelsea, in which the structural biologists in Dr van Montfort’s team are embedded, and will have access to its state-of-the art cryoEM facilities. These include an in-house Glacios and 30% direct access to a Titan KRIOS located at the Francis Crick Institute. Both microscopes are equipped with Falcon III detectors and volta phase plates (VPP). In addition, we have excellent access to the electron bioimaging Centre (eBIC) at the Harwell Science and Innovation campus, Didcot, UK. The postholder will be expected to work across the two sites in Chelsea, London and Sutton, Surrey. Applicants must have a PhD (or equivalent) in a biological or physical science, with experience in cryo-EM specimen preparation and data processing. Experience in single particle electron microscopy is essential for this post. Experience in molecular biology and protein expression in insect cells will be an advantage. The starting salary for the position will be in the range £32,844 to £40,902 p.a. inclusive (based on previous post-doctoral experience) and the post is offered on a fixed term contract of 18 months. Informal enquiries to rob.vanmontf...@icr.ac.uk<mailto:rob.vanmontf...@icr.ac.uk> or yann-vai.lebi...@icr.ac.uk<mailto:isaac.westw...@icr.ac.uk>. Please DO NOT send your application to Dr van Montfort or Dr Le Bihan, but apply via the e-recruitment system on our website www.icr.ac.uk<http://www.icr.ac.uk>. Closing date: 21st February 2021 Dr. Rob van Montfort Reader in Structural Biology and Cancer Drug Discovery Team Leader Hit Discovery and Structural Design Divisions of Cancer Therapeutics and Structural Biology The Institute of Cancer Research 15 Cotswold Road Sutton SM2 5NG UK Tel: +44-(0)20-8722-4364 (Sutton) +44-(0)20-7153-5142 (Chelsea) Email: rob.vanmontf...@icr.ac.uk<mailto:rob.vanmontf...@icr.ac.uk> The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company Limited by Guarantee, Registered in England under Company No. 534147 with its Registered Office at 123 Old Brompton Road, London SW7 3RP. This e-mail message is confidential and for use by the addressee only. If the message is received by anyone other than the addressee, please return the message to the sender by replying to it and then delete the message from your computer and network. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
