Three Research Associate positions are available in the laboratory of Prof. 
Luca Pellegrini in the Department of Biochemistry of the University of 
Cambridge, UK. 

The aim of the project is to elucidate key molecular mechanisms of DNA 
synthesis by the human replisome, the dynamic multi-protein ensemble 
responsible for duplicating chromosomal DNA before cell division. To achieve 
this goal, the successful candidates will use a multi-disciplinary approach 
that includes preparative biochemistry of multi-protein complexes, protein 
engineering and state-of-the-art biophysical and structural techniques.

Successful candidates will hold or be about to be awarded a PhD in 
Biochemistry, Biophysics or Molecular Biology. They must have a track record in 
conducting internationally competitive research, including peer-reviewed 
publications as first author. The ideal candidate will combine an ability to 
work independently and to fit in well in a team. Above all, she/he will be 
enthusiastic about pursuing fundamental research and be highly motivated to 
succeed professionally.

Expert knowledge of modern methods of preparative biochemistry and/or of 
quantitative biophysical methods is required. In particular, expertise in one 
or more of the following techniques is essential:
– Mammalian/insect-cell protein expression
– cryoEM (SPA and/or tomography)
– single-molecule fluorescence spectroscopy

Please apply at: https://www.jobs.cam.ac.uk/job/28616/ 
<https://www.jobs.cam.ac.uk/job/28616/>, quoting reference PH25609. Applicants 
should submit a CV with list of relevant publications, a cover letter 
explaining why they are suitable for the position and contact information for 
at least two referees.

Luca Pellegrini, PhD
Department of Biochemistry
University of Cambridge
Cambridge CB2 1GA
[email protected]


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