Dear Colleagues You are cordially invited to attend the virtual CBMS Lecture Series .....
An outlook on cryo-electron microscopy for structural and cellular biology Raimond Ravelli Associate Professor Institute of Nanoscopy (IoN), M4I, Fac. Health, Medicine and Life Sciences Maastricht University July 14, 2021, 13:30 (EDT) Register in advance for this meeting: https://bnl.zoomgov.com/meeting/register/vJIsdOCopzouHUg5FoLj2CPuhFjhAZo8yis Abstract Cryo-EM has become a powerful tool for structural and cellular biologists to study the structure-function relationships of their biomolecules of interest. Recent development of TEM hardware has led to atomic resolution for single particle cryo-EM, and near-atomic resolution for macromolecular complexes within cells. Most of the current successes have been reached using conventional phase contrast cryo-TEM. In this talk, I will discuss current limitations in cryo-EM such as sample preparation and detectors and show some of the developments therein. Could it become possible to solve a structure, as small as hen egg white lysozyme, by single particle cryo-EM? We will review alternative, exotic cryo-EM methods, with different information transfer functions. These include TEM techniques such as phase plate, multi-pass TEM, and off-axis holography, as well as STEM techniques, such as ptychography, and a quantum sorter. Vivian Stojanoff, PhD Education, Training, Outreach User Program Center for Biomolecular Structure National Synchrotron Light Source II Brookhaven National Laboratory p 1(631) 344 8375 e [email protected]<mailto:[email protected]> w https://www.bnl.gov/nsls2/lifesciences/ ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
