Hi,

Sorry for the off topic post. If anyone is passionate about working in an
exciting biotech powered by machine learning, structural biology, and
protein engineering, around Boston in the US, please check the link below.

https://www.linkedin.com/jobs/view/2662640332/efId=cCDvahCrRPGWslMQWMgEOQ%3D%3D

*Who we are*

Seismic Therapeutic is a VC-backed biotechnology startup focused on the
intersection of structure, protein engineering, machine learning and
immunology founded by Tim Springer, Jeff Ravetch, Debora Marks and Alan
Crane.

*What we offer you*

As a member of our new and quickly growing company, you’ll help us shape
Seismic from the very beginning into a startup that not only takes its
scientific mission seriously but also provides a positive and supportive
workplace environment and culture. Seismic will have the opportunity to
benefit from the insight, diversity, and talent that you’ll bring.
Together, we’ll help bring therapeutics to the patients who need them most.

*Our mission*

Seismic is determined to help patients in need, starting with novel
approaches to protein engineering, machine learning and immunology, and
ending with clinic-ready drugs. At our core, our focus is on phenomenal
science, meritocracy, a superstar team, supportive culture, and
patient-centric goals. Seismic has the tools, skills, ideas and people to
make this a reality – all we need is you! Success will enable treatment for
millions of patients with currently incurable, often disabling and deadly
diseases, and we invite you to become a part of that.

*Where?*

Seismic is located in the dynamic biotech community in Watertown, alongside
other new companies that are turning ideas into reality and changing the
biotech and medical scenes for the better. We are thrilled to expand our
Team with hardworking, highly qualified, highly motivated individuals to
join us in our lab space.

*Available position*

Scientist/Senior Scientist, Biochemistry and protein interactions

General role: In coordination with scientific leadership, you would play a
central role in designing and implementing Seismic’s pipeline, with
particular focus on processes occurring during biotherapeutic candidate
generation, screening and analysis. This role will involve exploring
customized solutions in the field of protein-protein interactions, followed
by detailed qualitative and quantitative sample analysis, leading into
high-throughput screening and characterization techniques. Successfully
meeting these challenges will require not only a broad range of protein
biochemistry skills, independent thinking, and an aptitude for
troubleshooting, but also a strong, creative drive to develop new assays as
the need arises.

Your work in this role would be in collaboration with scientists and
computational experts throughout Seismic, learning and contributing to many
aspects of our pipeline, including the iterative design and production of
biotherapeutics. You would be responsible for understanding project goals
and for creatively optimizing solutions to ensure their success. Over time
you would take on additional responsibilities and contribute to new
projects.

*Responsibilities*:

● Design and implement protocols for characterizing protein-protein
interactions.
● Design and optimize qualitative and quantitative biophysical and
biochemical studies of biotherapeutic molecules, including assay
development and protein QC.
● Share recommendations and insight for pipeline improvement toward
higher-throughput and efficiency
● Collaborate with a diverse team of wet-lab scientists, protein engineers,
and computational scientists
● Maintain an in depth understanding of the biochemistry, molecular
structure and wider role of each candidate through critical analysis of the
literature.

*Basic qualifications:*

● PhD in chemistry, biology, biochemistry, biomedical engineering, or
related field
● 5+ years hands-on wet lab experience, including at least two of the
following:
o Strong expertise in characterizing protein-protein interaction using
label free technologies such as interferometry (Octet) or surface plasmon
resonance (Biacore, Carterra)
o Direct experience with independent acquisition of kinetics and affinity
characterization datasets.
o Detailed experience in data analysis and reporting in kinetics and
affinity measurements.
o Capable at optimizing high-throughput protocols.
o Solid experience with protein biochemical analysis, including assay
development (eg. ELISA and ECLIA, etc) and protein quality control
characterizations.
● Strong collaborative, organizational, and presentation skills
● Ability to design and improve upon advanced protocols and procedures
● Ability to direct Research Associates, Technicians and CRO’s
● Ability to document, maintain, and share an organized account of lab work
and results



*Preferred qualifications:*
● 2+ years post PhD experience
● Understanding in immunology research and industrial biologics R&D
● Mentoring and managing experience

We are an Equal Opportunity employer committed to a diverse workforce. We
do not discriminate on the basis of race, religion, color, national origin,
gender, sexual orientation, age, marital status, veteran status or
disability.

Applicants please send an email to [email protected], including a
resume and a short self-introduction.

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