Dear CCP4BB fellows:
Glycans/sugars are the third, and possibly the structurally most diverse, class
of biopolymers (next to nucleic acids and proteins). All metazoan cells carry
complex glycans on their cell surfaces that are essential for life. We are
using the binding patterns of specific immunoreagents (single chain variable
fragment antibodies, or scFvs, and nanobodies) against a class of structurally
highly diverse glycans called heparan sulfates as a way to characterize
('glycotype') mammalian cell types. Preliminary data suggests that this
approach allows classification and identification of new cell types as well as
differentiation between healthy and diseased cells. For this multidisciplinary,
collaborative project between the labs of Drs. Steven Almo, Hannes Bülow,
Ulrich Steidl & Deyou Zheng at the Albert Einstein College of Medicine, we are
seeking a highly motivated postdoc who is interested in working at the
interface of protein engineering, structural biophysics and glycan biology to
study the logic of protein-sugar interactions of the heparan sulfate-specific
scFvs with their sugar binding partners. Prior experience in protein structural
biology is a plus but not required; interest in sugars and proteins is a must!
Candidates should send their research statement, CV, and the names and contact
information for three references to steve.almo<AT>einsteinmed.org
Regards,
Jbb for SCA
Jeffrey B. Bonanno, Ph.D.
Department of Biochemistry
Albert Einstein College of Medicine
1300 Morris Park Avenue
Bronx, NY 10461
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