Biochemist - Research Scientist
Company Description Sosei Heptares (the corporate brand of Sosei Group Corporation) is a research-focused biotechnology group, publicly listed in Japan (TSE: 4565) and with sites in Tokyo, London and Cambridge (UK). Our mission is to make a significant contribution to improving the quality of life and health of people around the world. To achieve this, we will discover, design and develop the most innovative and effective medicines for patients worldwide, through our world-leading patent-protected technology and platform. Our primary focus is the discovery and early development of new medicines originating from its proprietary G Protein-Coupled Receptor (GPCR)-targeted StaR® technology and Structure-Based Drug Design (SBDD) platform capabilities. The company is advancing a broad and deep pipeline of novel medicines across multiple therapeutic areas, including CNS, immuno-oncology, gastroenterology, inflammation and other rare/specialty indications. We have established partnerships with some of the world’s leading pharmaceutical companies, including Allergan, AstraZeneca, Daiichi-Sankyo, Genentech (Roche), Novartis, Pfizer and Takeda and additionally with multiple emerging technology companies Sosei Heptares has approximately 161 employees based at its new R&D research facility at Granta Park. The size of the company ensures a transparent linkage between all activities from early discovery through to clinical development. Position We are now seeking a membrane protein biochemist to join the Biochemistry group at our research facility on Granta Park, Cambridge, UK, working on membrane protein biochemical characterisation to enable drug discovery efforts. At Sosei Heptares we are equipped with state-of-the-art protein expression, purification, SPR, mass-spectrometry, crystallisation and cryoEM facilities. Applicants should have experience in the expression and purification of challenging membrane proteins destined for biochemical, biophysical and structural studies. Applicants with a proven track record of publications related to the expression, purification, and biochemical characterisation of difficult membrane protein targets in peer-reviewed journals would be advantageous. This is an exceptional opportunity to participate in pioneering science with an industry-leading drug discovery company. The successful candidate is expected to: • Express and purify membrane proteins • Perform appropriate quality control analyses and biochemically and biophysically characterise purified membrane proteins • Keep up to date, propose, develop, implement and optimise new techniques in the fields of membrane protein expression, purification and biochemical characterisation • Work together with scientists responsible for successfully progressing membrane protein targets through Sosei Heptares’ structure-based drug design pipeline • Collaborate with other Sosei Heptares scientists on research projects, working closely with molecular biologists, biophysicists, structural biologists, molecular pharmacologists, computational and medicinal chemists • Prepare and effectively present results (written and oral) to project teams • Have strong interpersonal skills and interact effectively with collaborators across a wide range of disciplines Requirements: The preferred candidate will have the following: • A PhD in biochemistry, biophysics or a related discipline • Experience in membrane protein expression, purification and characterisation in either an academic or industry setting • Good molecular biology skills • Knowledge in prokaryotic and eukaryotic expression vectors • Knowledge in expression construct design and engineering to successfully express membrane proteins destined for biochemical, biophysical and structural studies • Expertise in the expression of membrane proteins from mammalian and insect cells • Expertise in the purification and extensive biochemical characterisation of membrane proteins • Experience in the reconstitution of purified membrane proteins in membrane-mimetic environments • Familiarity with biochemical and biophysical techniques used to characterise membrane proteins such as luminescence, fluorescence and FRET-based techniques • Understanding of the requirements of purified membrane proteins destined for structural (X-ray and/or CryoEM) and biophysical studies (SPR, mass spectrometry) • Excellent organisational skills Other information The successful candidate will be employed by Heptares Therapeutics Ltd, a UK wholly owned subsidiary of Sosei Group Corporation. We offer a competitive salary, commensurate with qualifications and experience, and benefits package including pension and healthcare schemes. Applications should include your curriculum vitae and covering letter, providing a short description of the background to your interest in the role, with your application in pdf format, quoting reference number 2021-RS-1BMS. Please apply through our on-line jobs’ portal here: https://bit.ly/3BGbz65 The closing date for applications is 31st December 2021. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
