Happy New Year Everyone! We are recruiting a postdoctoral associate as described below.
A postdoctoral position is available immediately at Fox Chase Cancer Center (Philadelphia, PA) for a highly-motivated individual in the field of structural biology and protein biochemistry. Our lab aims to understand the molecular mechanisms underlying the signaling events mediated by integrins, small GTPases, as well as kinases, which have strong implications in cancer progression, metastasis and other human diseases, and to translate these knowledge into inhibitor/drug discovery. For this, we employ a combination of techniques including protein crystallography, electron microscopy, binding kinetics analysis, functional assays in mammalian cells, and genetic analysis. Our study will facilitate efforts to discover novel targets for therapeutic intervention of immune system disorders, tumor metastasis, and many other related diseases. (https://www.foxchase.org/people/jinhua-wu.) The candidate should hold a Ph.D. degree with strong experience in X-ray crystallography, protein biochemistry, and molecular biology. Prior experiences in mammalian cell culture, flow cytometry, drug screen, and cancer biology, are desired but not required. Fox Chase Cancer Center is a long-standing NCI-designated Comprehensive Cancer Center with multidisciplinary research interests from basic biological sciences to drug development and clinical studies. The institute is located in a quiet, safe, friendly neighborhood at the outskirts of the city. It is one of the top-ranked work places for visiting scholars and postdoctoral researchers. We also offer an outstanding research environment and strong support for the career development for our scientists. Please send a cover letter describing previous research experience and future plans, a current CV, a copy of graduate transcript, and a list of three references to: jinhua...@fccc.edu. Selected Recent Publications Zhang P, Azizi L, Kukkurainen S, Gao T, Baikoghli M, Jacquier MC, Sun Y, Maatta JAE, Cheng RH, Wehrle-Haller B, Hytonen VP, Wu J. Crystal structure of the FERM-folded talin head reveals the determinants for integrin binding. Proc Natl Acad Sci U S A. 2020. Epub 2020/12/09. doi: 10.1073/pnas.2014583117. PubMed PMID: 33288722. Kukkurainen S, Azizi L, Zhang P, Jacquier MC, Baikoghli M, von Essen M, Tuukkanen A, Laitaoja M, Liu X, Rahikainen R, Orlowski A, Janis J, Maatta JAE, Varjosalo M, Vattulainen I, Rog T, Svergun D, Cheng RH, Wu J, Hytonen VP, Wehrle-Haller B. The F1 loop of the talin head domain acts as a gatekeeper in integrin activation and clustering. J Cell Sci. 2020;133(19). Epub 2020/10/14. doi: 10.1242/jcs.239202. PubMed PMID: 33046605. Cho EA, Zhang P, Kumar V, Kavalchuk M, Zhang H, Huang Q, Duncan JS, Wu J. Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure. 2020. Epub 2020/12/05. doi: 10.1016/j.str.2020.11.011. PubMed PMID: 33275877. Chang YC, Su W, Cho EA, Zhang H, Huang Q, Philips MR, Wu J. Molecular basis for autoinhibition of RIAM regulated by FAK in integrin activation. Proc Natl Acad Sci U S A. 2019;116(9):3524-9. doi: 10.1073/pnas.1818880116. PubMed PMID: 30733287; PMCID: PMC6397589. Best wishes, Jinhua — Jinhua Wu Ph.D. Associate Professor Molecular Therapeutics Program Fox Chase Cancer Center W410 333 Cottman Ave. Philadelphia, PA 19111 215-728-2867 (office) 215-728-3616 (fax) ________________________________ This electronic message is intended to be for the use of the named recipient, and may contain information that is confidential or privileged. This communication may contain protected health information (PHI) that is legally protected from inappropriate disclosure by the Privacy Standards of the Health Insurance Portability and Accountability Act (HIPAA) and relevant Pennsylvania Laws. You can direct questions concerning PHI or HIPAA to the Corporate Compliance and Privacy Officer at (215) 707-5605. If you are not the intended recipient, please note that any dissemination, distribution or copying of this communication is strictly prohibited. If you have received this message in error, you should notify the sender immediately by telephone or by return e-mail and delete and destroy all copies of this message. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
