Dear all, Posting on behalf of Prof. Kalyan Das, Division of Virology & Chemotherapy, Rega Institute for Medical Research, KU Leuven, Belgium. Please contact at [email protected] if you are interested. Please share the advert with your colleagues and students.
*Postdoctoral Researcher in Structural Biology* The structural biology laboratory of Kalyan Das at Rega Institute, KU Leuven, Belgium invites applications from highly motivated researchers interested in pursuing a career in structure-based drug design using single-particle cryo-EM and X-ray crystallography. A candidate should have a Ph.D. degree in structural biology, molecular biology, chemical biology, biochemistry, or a related field with a proven track record. Strong hands-on experience in protein engineering, protein expression in bacterial and insect cells, and biophysical characterization is essential. Knowledge in structural biology is helpful, however, successful candidates will have the training opportunities to carry out structural studies by single-particle cryo-EM and crystallography. A qualified person should be a team player and should have strong writing and verbal communication skills. Rega Institute/KU Leuven provides a unique multi-disciplinary research platform, expertise, and cutting-edge facilities for drug discovery in an academic environment. Das’ lab studies structures and functions of viral polymerase, mitochondrial RNA polymerase, bacterial (mycobacterium tuberculosis) RNA polymerase, mammalian translation-translocon, etc. Our structural biology laboratory is equipped with a 200kV Glacios TEM with autoloader and direct electron detector, 600TB data server, Vitrobot Mark IV and Leica GP, GPU workstations for cryo-EM. The lab is also equipped with Akta Pure 25 integrated with Wyatt Optilab T-rEX, miniDAWN TREOS, and DynoPro NanoStar for purification and characterization of macromolecules, and Mosquito and JANSi UVEX robotic setups for high-throughput crystallization and crystal screening. Selected recent publications 1. Singh et al. Sliding of HIV-1 reverse transcriptase over DNA creates a transient P pocket - targeting P-pocket by fragment screening. *Nat Comm. *12:7127 (2021). 2. De Wijngaert, B., et al. Cryo-EM Structures Reveal Transcription Initiation Steps by Yeast Mitochondrial RNA Polymerase. *Mol Cell **81:*26 -280 (2021). 3. Gu, W., et al. Tenofovir-Amino Acid Conjugates Act as Polymerase Substrates- Implications for Avoiding Cellular Phosphorylation in the Discovery of Nucleotide Analogues. *J Med Chem. *64:782–796 (2021). Interested candidates are encouraged to send their biodata, list of publications, and names and email addresses of three referees to Kalyan Das, Professor, Division of Virology and Chemotherapy, Rega Institute/KU Leuven, Belgium. E-mail: [email protected] -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- Thank you. Abhi -- Dr. Abhimanyu Kumar Singh Research Fellow Laboratory of Virology & Chemotherapy, Rega Institute for Medical Research Department of Microbiology, Immunology and Transplantation, KU Leuven Herestraat 49, box 1030, 3000 Leuven Belgium. ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/WA-JISC.exe?SUBED1=CCP4BB&A=1 This message was issued to members of www.jiscmail.ac.uk/CCP4BB, a mailing list hosted by www.jiscmail.ac.uk, terms & conditions are available at https://www.jiscmail.ac.uk/policyandsecurity/
