Hi All,

I would like to draw your attention to the following open position at CHARM 
Therapeutics located in Cambridge, UK. 

Many thanks,

Dr Andy Dore


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For those that are interested, the application portal link is below:

https://s101.recruiting.eu.greenhouse.io/plans/4027860101


******

JOB DESCRIPTION

Scientist, Biochemistry
 
CHARM Therapeutics is a biotech company focused on delivering transformational 
medicines that will address difficult-to-drug targets in key oncogenic 
pathways. CHARM has developed the first highly accurate, high throughput 
protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep 
learning. Our platform enables the rapid generation of highly differentiated 
clinical candidates, and our ambition is to revolutionise drug discovery. CHARM 
Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK.  
 
We are currently seeking a motivated Biochemist to join the Structural Sciences 
group at CHARM Therapeutics. The position is within a lab-based team, working 
on high throughput crystallographic and CryoEM structural targets to fully 
enable and drive multiple SBDD / Med Chem campaigns.  The successful candidate 
will join a multidisciplinary, highly collaborative discovery team to invent 
novel medicines and drive them towards the clinic. 
 
Role Requirements:
 
The successful candidate will be expected to meet the following criteria:
 
A degree in biochemistry / molecular biology, or a related discipline, is 
required.

Experience in a biotech/pharma setting may be advantageous. 
 
Molecular biology / cloning / protein engineering skills and knowledgeable in 
expression construct design, and downstream purification strategies.
 
Demonstrable experience in the expression and purification of target proteins 
from recombinant systems (both bacterial and eukaryotic advantageous) utilising 
various affinity systems.
 
Experience in the use of FPLC systems and different approaches to purify 
recombinant target proteins to homogeneity.
 
Knowledgeable in the application of protein biochemistry to aspects of drug 
discovery programs including structural biology and biophysical analyses
 
Excellent organisational / interpersonal skills with the ability to work as 
part of a team.
 
What is on Offer:
 
The chance to work in a highly collaborative, progressive and intellectually 
stimulating environment, applying state of the art AI-based techniques to 
revolutionise drug discovery.
 
Competitive base salaries along with regular appraisals and reviews.
 
Share options in CHARM Therapeutics through the EMI scheme.
 
Private Healthcare, including dental and optical.
 
Gym membership.
 
Budget for employee development; training courses and conferences.
 
Fruit and snacks delivered to our offices.
 

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